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首页> 外文期刊>The British journal of psychiatry : >Lifetime affect and midlife cognitive function: prospective birth cohort study
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Lifetime affect and midlife cognitive function: prospective birth cohort study

机译：终生影响和中年认知功能：前瞻性出生队列研究

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Background Recurrent affective problems are predictive of cognitive impairment, but the timing and directionality, and the nature of the cognitive impairment, are unclear. Aims To test prospective associations between life-course affective symptoms and cognitive function in late middle age. Method A total of 1668 men and women were drawn from the Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). Longitudinal affective symptoms spanning age 13-53 years served as predictors; outcomes consisted of self-reported memory problems at 60-64 years and decline in memory and information processing from age 53 to 60-64 years. Results Regression analyses revealed no clear pattern of association between longitudinal affective symptoms and decline in cognitive test scores, after adjusting for gender, childhood cognitive ability, education and midlife socioeconomic status. In contrast, affective symptoms were strongly, diffusely and independently associated with self-reported memory problems. Conclusions Affective symptoms are more clearly associated with self-reported memory problems in late midlife than with objectively measured cognitive performance.
机译：背景反复出现的情感问题可以预测认知障碍，但是尚不清楚认知障碍的时间和方向以及其性质。目的测试中晚期生命过程情感症状与认知功能之间的前瞻性关联。方法从医学研究理事会国家健康与发展全国调查（英国1946年出生队列）中抽取1668名男女。跨越13-53岁的纵向情感症状可作为预测因素;结果包括60-64岁时自我报告的记忆问题以及53岁至60-64岁时记忆和信息处理能力的下降。结果回归分析显示，在调整了性别，儿童认知能力，教育程度和中年社会经济地位之后，纵向情感症状与认知测验得分下降之间没有明确的关联模式。相反，情感症状强烈，分散且独立地与自我报告的记忆问题相关。结论情感症状与中年后期自我报告的记忆问题相比，与客观测量的认知表现更明显相关。

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