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首页> 外文期刊>The British journal of psychiatry : >Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder
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Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder

机译：脑源性神经营养因子Val66Met多态性对重度抑郁症前额区的调节作用

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Background Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD. Aims To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions. Method Magnetic resonance imaging scans were acquired in 79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 years). Effects on surface area and cortical thickness were examined with multiple comparison correction. Results People who were Met allele carriers showed reduced caudal middle frontal thickness in both study groups. Significant interaction effects were found in the anterior cingulate and rostral middle frontal regions, in which participants in the MDD group who were Met carriers showed the greatest reduction in surface area. Conclusions Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
机译：背景脑源性神经营养因子（BDNF）Val66Met多态性有助于抑郁症的发展（重度抑郁症，MDD），但尚不清楚健康个体中观察到的神经作用是否在MDD中得以维持。目的研究BDNF Val66Met对MDD神经回路关键区域的作用：杏仁核，前扣带回，额中部和眶额区域。方法对79名MDD患者（平均年龄49岁）和74名健康志愿者（平均年龄50岁）进行了磁共振成像扫描。通过多次比较校正检查了对表面积和皮质厚度的影响。结果在两个研究组中，作为等位基因携带者的人尾中额厚度均减少。在前扣带回和延髓中额叶区域发现了显着的相互作用效应，其中作为Met携带者的MDD组参与者显示出最大的表面积减少。结论BDNF Val66Met多态性对MDD前额叶皮层不同亚区的调节作用支持抑郁症的神经营养蛋白模型。

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