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首页> 外文期刊>The British journal of psychiatry : >Handedness, language lateralisation and anatomical asymmetry in schizophrenia
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Handedness, language lateralisation and anatomical asymmetry in schizophrenia

机译：精神分裂症的手性，语言偏侧化和解剖学不对称

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Background Cerebral lateralisation appears to be decreased in schizophrenia. Results of studies investigating this, however, are equivocal. Aims To review quantitatively the literature on decreased lateralisation in schizophrenia. Method Meta-analyses were conducted on 19 studies on handedness, 10 dichotic listening studies and 39 studies investigating anatomical asymmetry in schizophrenia. Results The prevalence of mixed- and left-handedness (a€?non-right-handednessa€?) was significantly higher in patients with schizophrenia as compared to healthy controls, and also as compared to psychiatric controls. The analysis of dichotic listening studies revealed no significant difference in lateralisation in schizophrenia. However, when analysis was restricted to studies using consonanta€”vowel or fused word tasks, significantly decreased lateralisation in schizophrenia emerged. Asymmetry of the planum temporale and the Sylvian fissure was significantly decreased in schizophrenia, while asymmetry of the temporal horn of the lateral ventricle was not. Conclusion Strong evidence is provided for decreased cerebral lateralisation in schizophrenia.
机译：背景在精神分裂症中，脑侧偏似乎有所减少。但是，研究此结果的结果是模棱两可的。目的定量评估有关精神分裂症患者偏侧化的文献。方法对19个关于惯性的研究，10个二项听觉研究和39个研究精神分裂症的解剖学不对称性的研究进行了荟萃分析。结果与健康对照者和精神病对照者相比，精神分裂症患者混合和左手性（非右手性）的患病率显着更高。对二项听觉研究的分析表明，精神分裂症的侧向化没有显着差异。但是，当分析仅限于使用重音元音或融合词任务的研究时，出现了精神分裂症的明显侧倾现象。精神分裂症的颞侧颞叶和Sylvian裂孔的不对称性明显降低，而侧脑室颞角的不对称性则没有。结论强有力的证据为精神分裂症患者的脑外侧化程度降低提供了证据。

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