Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia

LARRY J. SEIDMAN; MING T. TSUANG; STEPHEN J. GLATT; STEPHEN V. FARAONE; WILLIAM S. STONE

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Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia

机译：精神分裂症患者一级直系亲属的心理病理学，人格特征和社会发展

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Background Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness. Aims To identify aspects of personality, psychopathology and social development that differentiate high-risk and control individuals. Method Adolescent and young-adult first-degree relatives ( n =35) of people with schizophrenia or schizoaffective disorder and a control group ( n =55) were compared on 36 measures at baseline of a longitudinal study. Measures differentiating high-risk and control participants were related to four genetic loading indices. Results High-risk participants older than 17 years showed more physical anhedonia, less positive involvement with peers and more problems with peers, siblings and the opposite gender. Older high-risk individuals also were less cooperative, less self-directed and less reward-dependent. Problems with peers and the opposite gender, as well as reward dependence, were related linearly to genetic loading. Conclusions Alterations in personality traits and social development are present in high-risk individuals, and may be markers for genetic liability toward the illness.

机译：背景对精神分裂症具有高遗传风险的个体进行评估是确定疾病前兆的有效方法。目的确定个性，心理病理学和社会发展方面与高风险和控制个体不同的方面。方法在纵向研究的基线时，对36位患者进行比较，对精神分裂症或分裂情感障碍患者的青少年和青少年一级亲属（n = 35）和对照组（n = 55）进行了比较。区分高风险和控制参与者的措施与四个遗传负荷指数有关。结果年龄大于17岁的高风险参与者表现出身体性快感不足，与同伴的积极参与减少，同伴，兄弟姐妹和异性的问题更多。年龄较大的高风险个体也较不合作，较少自我指导和较少依赖奖励。同伴和异性的问题以及奖励依赖与遗传负荷呈线性关系。结论高危人群存在人格特质和社会发展的改变，这可能是该病遗传责任的标志。

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《The British journal of psychiatry :》 |2006年第4期|共页
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LARRY J. SEIDMAN; MING T. TSUANG; STEPHEN J. GLATT; STEPHEN V. FARAONE; WILLIAM S. STONE;
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机译：精神分裂症患者年轻一级亲属的精神病理学，人格特征和社会发展

Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia

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