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首页> 外文期刊>The British journal of psychiatry : >Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes
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Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes

机译：使用BDNF单倍型的精神分裂症精神分裂情感障碍的分子分化

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Background Allelic variation in the gene encoding brain-derived neurotrophic factor ( BDNF ) has been associated with affective disorders, but generally not schizophrenia. Brain-derived neurotrophic factor variants may help clarify the status of schizoaffective disorder. Aims To test the hypothesis that BDNF haplotypes are associated with psychiatric illness marked by a prominent affective component. Method Frequencies of a 5-marker BDNF haplotype were examined in 600 White participants across four diagnostic categories and healthy controls. Results Individuals with schizoaffective disorder and other affective disorders were significantly more likely to carry two copies of the most common BDNF haplotype (containing the valine allele of the Val66Met polymorphism) compared with healthy volunteers. Moreover, when compared with people with schizophrenia, individuals with schizoaffective disorder were significantly more likely to carry two copies of the common haplotype. Conclusions To our knowledge, this is the first candidate gene study to demonstrate association with schizoaffective disorder but not schizophrenia. Variation in the BDNF gene may be associated with the clinical phenotype of affective dysregulation across several DSMa€“IV diagnostic categories.
机译：背景编码脑源性神经营养因子（BDNF）的基因的等位基因变异与情感障碍有关，但通常与精神分裂症无关。脑源性神经营养因子变异体可能有助于阐明精神分裂情感障碍的状况。目的为了检验BDNF单倍型与以显着的情感成分为特征的精神病相关的假说。方法在600名白人受试者中，对四个诊断类别和健康对照者的5标记BDNF单倍型频率进行了检查。结果与健康志愿者相比，患有分裂情感障碍和其他情感障碍的人携带最常见的BDNF单倍型（包含Val66Met多态的缬氨酸等位基因）的两个副本的可能性更高。此外，与精神分裂症患者相比，患有分裂情感障碍的患者携带两份普通单倍型的可能性更高。结论据我们所知，这是第一个证明与精神分裂症有关但与精神分裂症无关的候选基因研究。 BDNF基因的变异可能与几种DSMa IV诊断类型的情感失调的临床表型有关。

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