• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pneumonia. >Acute respiratory infection and bacteraemia as causes of non-malarial febrile illness in African children: a narrative review
【24h】

Acute respiratory infection and bacteraemia as causes of non-malarial febrile illness in African children: a narrative review

机译：急性呼吸道感染和菌血症是非洲儿童非疟疾热病的病因：叙事回顾

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The replacement of “presumptive treatment for malaria” by “test before treat” strategies for the management of febrile illness is raising awareness of the importance of knowing more about the causes of illness in children who are suspected to have malaria but return a negative parasitological test. The most common cause of non-malarial febrile illness (NMFI) in African children is respiratory tract inflection. Whilst the bacterial causes of NMFI are well known, the increasing use of sensitive techniques such as polymerase chain reaction (PCR) tests is revealing large numbers of viruses that are potential respiratory pathogens. However, many of these organisms are commonly present in the respiratory tract of healthy children so causality and risk factors for pneumonia remain poorly understood. Inflection with a combination of viral and bacterial pathogens is increasingly recognised as important in the pathogenesis of pneumonia. Similarly, blood stream inflections with organisms typically grown by aerobic culture are well known but a growing number of organisms that can be identified only by PCR, viral culture, or serology are now recognised to be common pathogens in African children. The high mortality of hospitalised children on the first or second day of admission suggests that, unless results are rapidly available, diagnostic tests to identify specific causes of illness will still be of limited use in guiding the potentially life saving decisions relating to initial treatment of children admitted to district hospitals in Africa with severe febrile illness and a negative test for malaria. Malaria control and the introduction of vaccines against Haemophilus influenzae type b and pneumococcal disease are contributing to improved child survival in Africa. However, increased parasitological testing for malaria is associated with increased use of antbiotics to which resistance is already high.
机译：用“先治疗后治疗”策略取代“推定治疗疟疾”策略来治疗高热疾病，这使人们认识到，更多地了解疑似患有疟疾但返回阴性寄生虫测试的儿童的病因的重要性。非洲儿童非疟疾高热病（NMFI）的最常见原因是呼吸道弯曲。尽管NMFI的细菌原因是众所周知的，但是越来越多的敏感技术（例如聚合酶链反应（PCR）测试）的使用正在揭示大量潜在的呼吸道病原体病毒。但是，许多此类生物通常存在于健康儿童的呼吸道中，因此对肺炎的因果关系和危险因素的了解仍然很少。越来越多的病毒和细菌病原体联合感染在肺炎的发病机理中被认为是重要的。同样，众所周知，通常通过有氧培养产生的生物体的血流变化，但是越来越多的只能通过PCR，病毒培养或血清学鉴定的生物体现在被认为是非洲儿童的常见病原体。住院儿童在入院第一天或第二天的高死亡率表明，除非能够迅速获得结果，用于确定特定病因的诊断测试在指导与儿童初次治疗有关的可能挽救生命的决定方面仍然将受到限制。被送往非洲的地区医院，患有严重的高热疾病，疟疾呈阴性。疟疾的控制和针对b型流感嗜血杆菌和肺炎球菌疾病的疫苗的引入正在改善非洲儿童的生存。然而，对疟疾的寄生虫学测试的增加与对抗生素的耐药性已经增加的抗生素的使用增加有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号