...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Indian journal of medical research >Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections
【24h】

Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections

机译：肺炎支原体：小儿社区获得性下呼吸道感染中的一种重要但被低估的病原体

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lower respiratory tract infections are considered a common cause responsible for morbidity and mortality among children, and Mycoplasma pneumoniae is identified to be responsible for up to 40 per cent of community-acquired pneumonia in children greater than five years of age. Extrapulmonary manifestations have been reported either due to spread of infection or autoimmune mechanisms. Infection by M. pneumoniae has high incidence and clinical importance but is still an underrated disease. Most widely used serologic methods are enzyme immunoassays for detection of immunoglobulin M (IgM), IgG and IgA antibodies to M. pneumoniae, though other methods such as particle agglutination assays and immunofluorescence methods are also used. Detection of M. pneumoniae by nucleic acid amplification techniques provides fast, sensitive and specific results. Utilization of polymerase chain reaction (PCR) has improved the diagnosis of M. pneumoniae infections. Besides PCR, other alternative amplification techniques include (i) nucleic acid sequence-based amplification, (ii) Qβ replicase amplification, (iii) strand displacement amplification, (iv) transcription-mediated amplification, and (v) ligase chain reaction. Macrolides are used as the first-line treatment in childhood for M. pneumoniae infections; however, emergence of macrolide-resistant M. pneumoniae is a cause of concern. Development of a safe vaccine is important that gives protective immunity and would be a major step in reducing M. pneumoniae infections.
机译：下呼吸道感染被认为是造成儿童发病和死亡的常见原因，而肺炎支原体被鉴定为五岁以上儿童中社区获得性肺炎的多达40％。据报道，由于感染扩散或自身免疫机制，肺外表现。肺炎支原体感染具有很高的发病率和临床重要性，但仍被低估。最广泛使用的血清学方法是用于检测针对肺炎支原体的免疫球蛋白M（IgM），IgG和IgA抗体的酶免疫法，尽管也使用了其他方法，例如颗粒凝集法和免疫荧光法。通过核酸扩增技术检测肺炎支原体可提供快速，灵敏和特异的结果。利用聚合酶链反应（PCR）改善了肺炎支原体感染的诊断。除PCR以外，其他替代扩增技术还包括（i）基于核酸序列的扩增，（ii）Qβ复制酶扩增，（iii）链置换扩增，（iv）转录介导的扩增和（v）连接酶链反应。大环内酯类药物在儿童中被用作肺炎支原体感染的一线治疗。然而，引起大环内酯类耐药的肺炎支原体的出现令人担忧。安全疫苗的开发对提供保护性免疫很重要，并且是减少肺炎支原体感染的重要一步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号