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首页> 外文期刊>The Internet Journal of Pharmacology >Fast Dissolving Drug Delivery Systems: A Brief Overview
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Fast Dissolving Drug Delivery Systems: A Brief Overview

机译：快速溶解药物输送系统：简要概述

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Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms (tablets, capsules, solutions and suspensions) because of tremors of extremities and dysphagia. Fast-dissolving drug delivery systems may offer a solution for these problems. Introduction Drug delivery systems (DDS) are a strategic tool for expanding markets/indications, extending product life cycles and generating opportunities. DDS make a significant contribution to global pharmaceutical sales through market segmentation, and are moving rapidly.Fast dissolving drug delivery (FDDTs,) can be achieved by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, sublimation. In order to allow fast dissolving tablets to dissolve in the mouth, they are made of either very porous and soft- moulded matrices or compressed into tablets with very low compression force, which makes the tablets friable and/or brittle, which are difficult to handle, often requiring specialized peel-off blister packaging.Many pharmaceutical dosages are administered in the form of pills, granules, powders, and liquids. Generally, a pill design is for swallowing intact or chewing to deliver a precise dosage of medication to patients. The pills, which include tablets and capsules, are able to retain their shapes under Moderate pressure. However, some patients, particularly pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take these solid preparations due to a fear of choking. In order to assist these patients, several fast-dissolving drug delivery systems have been developed. Fast-dissolving drug delivery1 In recent years, a variety of improved methods for delivering drugs have been developed with the aim of improving performance, convenience and complianceFDDTs disintegrate and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. When put on tongue, this tablet disintegrates instantaneously, releasing the drug, which dissolves or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form2,3 The advantage of Fast Dissolving Dosage Forms are increasingly being recognized in both industry and academia4 Advantages of Fast Dissolving Drug Delivery System FDDTs,,,,, Fast dissolving technology offers : Improved compliance/added convenience No water needed No chewing needed Better taste Improved stability Suitable for controlled/sustained release actives Allows high drug loading. Ability to provide advantages of liquid medication in the form of solid preparation. Adaptable and ameanable to existing processing and packaging machinery Cost- effective Needs The need for non-invasive delivery systems continues due to patients' poor acceptance and compliance with existing delivery regimes, limited market size for drug companies and drug uses, coupled with high cost of disease management.The current needs of the industry are improved solubility/stability, biological half-life and bioavailability enhancement of poorly absorbed drugs. Key issues facing the biopharma industry are to improve safety (decreasing gastrointestinal side effects), improve efficacy for organ targeting, and improved compliance via sustained
机译：近来，快速溶解的药物输送系统已经开始流行并被接受为新的药物输送系统，因为它们易于管理并且可以改善患者的依从性。通常，由于四肢震颤和吞咽困难，老年人难以吞咽常规剂型（片剂，胶囊剂，溶液剂和混悬剂）。快速溶解的药物输送系统可以为这些问题提供解决方案。简介药物输送系统（DDS）是扩展市场/适应症，延长产品生命周期并创造机会的战略工具。 DDS通过市场细分为全球药品销售做出了重大贡献，并且正在迅速发展。快速溶解药物输送（FDDT）可以通过各种常规方法来实现，例如直接压片，湿法制粒，成型，喷雾干燥，冷冻干燥，升华。为了使快速溶解的片剂在口中溶解，它们由非常多孔且软模制的基质制成，或以非常低的压缩力压缩成片剂，这使得片剂易碎和/或易碎，难以处理，通常需要专门的剥离式泡罩包装。许多药物剂型以丸剂，颗粒剂，散剂和液体剂的形式给药。通常，丸剂设计是为了完整吞咽或咀嚼以向患者递送精确剂量的药物。这些药丸包括片剂和胶囊剂，能够在中等压力下保持其形状。然而，一些患者，特别是儿科和老年患者，难以吞咽或咀嚼固体剂型。由于担心窒息，许多儿科和老年患者不愿服用这些固体制剂。为了帮助这些患者，已经开发了几种快速溶解的药物递送系统。快速溶解的药物输送1近年来，为了改善性能，便利性和顺应性，已经开发了多种改进的药物输送方法，FDDT在唾液中迅速分解和/或溶解，而无需水。一些片剂被设计为在几秒钟内显着地快速溶解在唾液中，并且是真正的速溶片剂。其他的包含增加片剂在口腔中的崩解速率的试剂，并且更合适地称为快速崩解的片剂，因为它们可能需要一分钟才能完全崩解。戴在舌头上时，该片剂会立即崩解，释放出可溶解或分散在唾液中的药物。随着唾液向下进入胃，一些药物会从口腔，咽和食道吸收。在这种情况下，药物的生物利用度显着高于常规片剂剂型2、3。快速溶解剂型的优势已在业界和学术界得到越来越多的认可4。快速溶解药物输送系统FDDT的优势溶解技术提供：改进的顺应性/增加的便利性不需要水不需要咀嚼更好的口味改进的稳定性适合控制/缓释活性成分允许高载药量。能够以固体制剂形式提供液体药物的优势。适应并适应现有加工和包装机械的成本效益需求由于患者对现有的给药方式的接受程度不佳和依从性不佳，药品公司和药品使用的市场规模有限以及成本高昂，对无创给药系统的需求持续存在疾病管理：该行业当前的需求是提高溶解度/稳定性，生物半衰期和吸收不良的药物的生物利用度。生物制药行业面临的关键问题是提高安全性（减少胃肠道副作用），提高器官靶向的功效以及通过持续的治疗改善依从性

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