• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The International Journal of Alcohol and Drug Research >Neurobiological research on addiction: What value has it added to the concept?
【24h】

Neurobiological research on addiction: What value has it added to the concept?

机译：关于成瘾的神经生物学研究：它为概念增加了什么价值？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Kalant, H. (2015). Neurobiological research on addiction: What value has it added to the concept?. The International Journal Of Alcohol And Drug Research, 4 (1), 53-59. doi: http://dx.doi.org/10.7895/ijadr.v4i1.196 The initial goal of neurobiological research on addiction was to identify the neural mechanisms involved in the mediation and expression of addictive behavior. More recently, however, it has attributed causal roles to these mechanisms, as illustrated by the definition of addiction as a brain disease caused by chronic exposure to a drug. This concept carries a number of implications that can be assessed experimentally and clinically. None of these implications is borne out by the currently available evidence. The interactions of neuronal systems involved in addiction are also involved in adaptation to experience and environmental change. Much of the neurobiological research to date has not differentiated between causes of addiction, neuronal mechanisms that are activated by them, and risk factors that contribute to individual vulnerability. It has largely ignored the important experiential and environmental influences known to affect the prevalence of addiction in different populations or different times, and it has so far directed much less attention to other forms of addiction-like behavior that do not involve drugs. These failures are not inherent in neurobiological research but require reorientation of objectives, including more emphasis on the study of mechanisms by which environment and experience, including drug experience, can determine whether genetic risk factors are expressed or remain dormant and can direct neuroadaptive mechanisms toward alternative outcomes.
机译：Kalant，H.（2015年）。关于成瘾的神经生物学研究：它为概念增加了什么价值？国际酒精与药物研究杂志，4（1），53-59。 doi：http：//dx.doi.org/10.7895/ijadr.v4i1.196关于成瘾的神经生物学研究的最初目标是确定与成瘾行为的介导和表达有关的神经机制。然而，近来，它已将致病作用归因于这些机制，如将成瘾定义为由长期暴露于药物引起的脑病。这个概念带有许多含义，可以通过实验和临床进行评估。目前可用的证据都不能证明这些含义。与成瘾有关的神经系统的相互作用也与适应经验和环境变化有关。迄今为止，许多神经生物学研究还没有区分成瘾的原因，由它们激活的神经元机制，以及导致个人脆弱性的危险因素。它在很大程度上忽略了已知的重要经验和环境影响，这些影响影响成瘾在不同人群或不同时期的流行，迄今为止，它已将注意力更多地转移到不涉及毒品的其他形式的成瘾样行为上。这些失败并非神经生物学研究固有的，而是需要重新定位目标，包括更加注重环境和经验（包括药物经验）可以确定遗传风险因素是否表达或保持休眠并可以将神经适应性机制引向其他机制的机制的研究。结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号