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首页> 外文期刊>The Internet journal of parasitic diseases >Genital Trichomoniasis Among Women At A University Teaching Hospital: Findings From A Study On 8,443 Clinical Urogenital Samples In Jos, North Central Nigeria.
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Genital Trichomoniasis Among Women At A University Teaching Hospital: Findings From A Study On 8,443 Clinical Urogenital Samples In Jos, North Central Nigeria.

机译：一家大学教学医院的女性中的生殖器滴虫病：对尼日利亚中北部乔斯的8,443例临床泌尿生殖道样本的研究结果。

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Aim: The study was set to ascertain the incidence of Trichomonas vaginalis among women in Jos. Methods: The study was retrospective in nature. Data generated by the Microbiology laboratory of the Jos University Teaching Hospital (JUTH) on high vaginal swab/endocervical swab (HVS/ECS) samples was compiled for a period of five years (July 2000-June 2005). Samples were collected, transported, stored and processed using standard laboratory procedures. Additional information was obtained from patients' records. Results were analysed using Epi Info 6 statistical software, while P values <0.05 were considered significant. Results: The incidence of T. vaginalis among women was found to 1.2% in Jos. The peak age of infection was 20-29 years, and there was no significant age difference (P> 0.05). Clinical features associated with T. vaginalis infection include: Nil 6.7%, Itching + Rashes 10.6%, Discharge only 35.6%, Rashes only 8.6%, Itching + Discharge 27.9%, and Itching only 4.8%. Conclusion: T. vaginalis is not a rare STD among women in Jos. Proper sex education especially for the youths and adolescents should be intensified so as to ensure a population fully aware of the Dos and Don'ts of STDs and hence reduce the spread and rate of infection with T. vaginalis and other STDs. Introduction Trichomonas vaginalis is a trophozoite; oval in shape as well as flagellated. Five flagella arise near the cytosome; four of these immediately extend outside the cell together, while the fifth flagellum wraps backwards along the surface of the organism1,2. T. vaginalis is an established cause of sexually transmitted diseases (STDs), and currently affects at least170 million people worldwide; more than gonorrhea, syphilis and Chlamydia combined3,4,5. The organism has been reported to cause pneumonia, bronchitis and oral lesions6,7, while a greenish-yellow frothy vaginal secretion and itching are its commonest presentations8,9,10,11. Infertility, premature rupture of membranes, preterm labor, and abortions have all been associated with the organism7,8,9. T. vaginalis, though generally believed to be a female agent has been detected in between 11% to 17% of men attending STD clinic in which it was the sole organism detected in the urethra12,13. In North Carolina USA, T. vaginalis was detected in 29% of women attending an STD clinic using polymerase chain reaction (PCR)14; while in Dhaka, Bangladesh, T. vaginalis was detected in 45.5% of the 269 street-based female sex workers15. Also in Cotonou, Benin, T. vaginalis was detected in 10.5% of female commercial sex workers16. T. vaginalis has been reported to induce cervical intraepithelial neoplasia (CIN) (a premalignant condition) faster than the hitherto strongly associated organisms17,18. In India it was found that, CIN detected by cytology was detected in 7.04%, 4.89% and 4.89% of women infected with T. vaginalis, herpes simplex virus, and human papilloma virus respectively19. T. vaginalis has also been shown to induce epithelial monolayer disruption, creating a microenvironment conducive for HIV-I replication20, a phenomenon which could encourage the spread of HIV infection21,22,23,24,25. Recent findings have shown a gradual built up of metrinodazole resistant T. vaginalis 26,27, the drug of choice for its treatment. This has been attributed to a reduction in transcription of the ferrodoxin gene thereby decreasing the ability of the cell to activate the drug28. This has constituted a potential challenge towards the future management of trichomoniasis27,28.In Nigeria, Nwosu, et al reported T. vaginalis prevalence of 12.5% among females in a cross-sectional study29, while Akerele, et al, in Benin-city30, reported about 15% detection of the organism among pregnant women, Papin, et al from a study on 659 men with urethral discharge reported T. vaginalis to account for 13.8% of the cases across West Africa31. Among the agents of STDs, T. vaginalis, though fairly researched, appears to attract less enthus
机译：目的：该研究旨在确定乔斯女性阴道毛滴虫的发病率。方法：该研究具有回顾性。乔斯大学教学医院（JUTH）的微生物实验室生成的有关高阴道拭子/宫颈内拭子（HVS / ECS）样本的数据进行了为期五年（2000年7月至2005年6月）的收集。使用标准实验室程序收集，运输，存储和处理样品。从患者记录中获得了更多信息。使用Epi Info 6统计软件分析结果，而P值<0.05被认为是显着的。结果：乔斯地区女性阴道锥虫的发生率为1.2％，感染高峰年龄为20-29岁，年龄差异无统计学意义（P> 0.05）。与阴道锥虫感染相关的临床特征包括：无6.7％，瘙痒+皮疹10.6％，仅排出35.6％，皮疹仅8.6％，瘙痒+排出27.9％，仅瘙痒4.8％。结论：阴道锥虫在乔斯妇女中并非罕见的性传播疾病，应加强对性行为的正确教育，尤其是对青少年的性教育，以确保人们充分意识到性传播疾病的注意事项，从而减少其传播和传播。阴道锥虫和其他性病的感染率。前言阴道毛滴虫是滋养体。椭圆形和鞭毛状。在细胞体附近出现五个鞭毛;其中四个立即一起延伸到细胞外，而第五鞭毛沿生物体表面向后包裹1,2。阴道T.是性传播疾病（STD）的既定原因，目前影响全世界至少1亿7千万人;多于淋病，梅毒和衣原体的合并3、4、5。据报道该生物体引起肺炎，支气管炎和口腔损伤6,7，而绿黄色泡沫状阴道分泌物和瘙痒是其最常见的表现[8,9,10,11]。不育症，胎膜​​早破，早产和流产都与生物体有关[7,8,9]。尽管通常被认为是女性病原体，但在性病门诊就诊的男性中，有11％至17％的人检出了阴道T.12，这是尿道中唯一的生物体[12,13]。在美国北卡罗来纳州，使用聚合酶链反应（PCR）14在前往性病门诊就诊的女性中检测到29％的阴道T.而在孟加拉国的达卡市，在269名街头女性工作者中有45.5％检出了阴道T.15。同样在贝宁的科托努，在10.5％的女性商业性工作者中发现了阴道锥虫16。据报道，阴道锥虫诱导宫颈上皮内瘤变（CIN）（恶性前病）的速度要快于迄今高度相关的生物体17，18。在印度发现，通过细胞学检测的CIN分别在感染了阴道锥虫，单纯疱疹病毒和人乳头瘤病毒的妇女中占7.04％，4.89％和4.89％。还已证明阴道锥虫可诱导上皮单层破坏，从而创造有利于HIV-1复制的微环境20，这种现象可能会促进HIV感染的扩散21、22、23、24、25。最近的发现显示逐渐增加了对美诺达唑耐药的阴道锥虫26,27的治疗，这是其治疗的选择药物。这归因于铁氧还蛋白基因转录的减少，从而降低了细胞激活药物的能力28。这对未来的滴虫病的治疗构成了潜在的挑战27,28。在尼日利亚，Nwosu等人在一项横断面研究中报告了女性阴道阴道曲霉菌患病率为12.5％29，而在贝宁市的Akerele等人30， Papin等人对659名尿道分泌物的男性进行的一项研究报告说，在孕妇中检出该微生物的比例约为15％，其中阴道锥虫占整个西非病例的13.8％31。在性传播疾病的病原体中，尽管经过了充分的研究，但阴道锥虫似乎吸引了较少的热情。

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