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首页> 外文期刊>The Journal of Nuclear Medicine >The F+0 Protocol for Diuretic Renography Results in Fewer Interrupted Studies Due to Voiding Than the F-15 Protocol
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The F+0 Protocol for Diuretic Renography Results in Fewer Interrupted Studies Due to Voiding Than the F-15 Protocol

机译：利尿肾造影的F + 0方案比F-15方案无效，导致更少的中断研究

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id="p-1">Timing of diuretic administration is not universally standardized in renography. Over the past year, our practice has changed from F-15 administration of furosemide to an F+0 protocol. Therefore, we have retrospectively compared these 2 cohorts to assess if the shorter interval between diuretic administration and study completion in the F+0 study results in a greater frequency of patients able to complete the subsequent 30-min dynamic acquisition without disruption due to voiding. >Methods: We identified 108 diuretic 99mTc-mercaptoacetyltriglycine renograms performed in the previous 18-mo period. Three patients were given furosemide at 30 min after the radiopharmaceutical and were excluded. Twenty studies in children under 3 y of age were excluded from consideration because voiding is neither restricted in this age group nor does voiding into a diaper cause disruption. Forty milligrams of furosemide were administered to adults, whereas 0.5 mg/kg was given to children. In the first cohort of 56 studies, radiopharmaceutical was administered 15 min after furosemide (F-15), whereas, in the second cohort of 29 patients, it was administered immediately thereafter (F+0). In all cases, patients were asked to void proximal to radiopharmaceutical injection. Dynamic images and renogram curves were inspected for evidence of interruption or voiding midstudy. Statistical significance was determined by a 1-tailed Fisher exact test for proportions, with P 0.05. >Results: The F-15 and F+0 groups of patients were comparable in terms of age, sex, and diuretic amount. In 17 of the F-15 patients, renography was interrupted because of voiding (30%), whereas this occurred in only 3 of the F+0 patients (10%). This difference was significant at the P = 0.033 level. The mean time of voiding was 18.3 min (range, 12-25 min) for F-15 patients and 16 min (range, 12-19 min) for the F+0 group. >Conclusion: The F+0 renal diuretic protocol is associated with a significantly lower rate of disruption because of voiding than the F-15 protocol, likely due to the shorter period between diuretic administration and study termination, which results in less bladder distention and discomfort. On the basis of these data, the F+0 protocol appears to be a more tolerable procedure.
机译：id =“ p-1”>利尿剂的给药时间在肾病学检查中尚未普遍标准化。在过去的一年中，我们的做法已经从F-15速尿改为F + 0方案。因此，我们回顾性地比较了这两个队列，以评估在F + 0研究中利尿剂给药和研究完成之间的较短时间间隔是否导致患者能够更频繁地完成随后的30分钟动态采集而不会因排尿而中断。 >方法：我们确定了在前18个月内进行的108张利尿药 99m Tc-巯基乙酰基三甘氨酸肾图。 3名患者在放疗后30分钟接受了速尿治疗，但被排除在外。排除了在3岁以下儿童中进行的20项研究，因为该年龄组的排尿既不受限制，排尿也不会对尿布造成破坏。成人服用40毫克的呋塞米，儿童服用0.5毫克/千克。在56项研究的第一个队列中，在速尿（F-15）后15分钟施用了放射性药物，而在29例患者的第二个队列中，此后立即进行了放疗（F + 0）。在所有情况下，都要求患者在放射性药物注射的近端排空。检查动态图像和肾图曲线是否有中途学习中断或无效的证据。统计显着性是通过1-尾Fisher精确检验比例确定的， P <0.05。 >结果：F-15和F + 0组的患者在年龄，性别和利尿剂量方面具有可比性。在F-15患者中的17例中，由于排尿而中断了肾脏造影（30％），而在F + 0患者中只有3例（10％）发生了肾脏造影。在 P = 0.033的水平上，这种差异是显着的。 F-15患者的平均排尿时间为18.3分钟（范围12-25分钟），F + 0组为16分钟（范围12-19分钟）。 >结论：与F-15方案相比，F + 0肾利尿剂方案的排空率明显低于F-15方案，这可能是由于利尿剂给药和研究终止之间的时间较短导致的。减少膀胱膨胀和不适。根据这些数据，F + 0协议似乎是更可容忍的过程。

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