...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutrition: Official Organ of the American Institute of Nutrition >Maternal DHA Equilibrium during Pregnancy and Lactation Is Reached at an Erythrocyte DHA Content of 8 g/100 g Fatty Acids
【24h】

Maternal DHA Equilibrium during Pregnancy and Lactation Is Reached at an Erythrocyte DHA Content of 8 g/100 g Fatty Acids

机译：孕妇和哺乳期的母体DHA平衡达到8 g / 100 g脂肪酸的红细胞DHA含量

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Low long-chain PUFA (LC-PUFA, or LCP) consumption relates to suboptimal neurodevelopment, coronary artery disease, and [postpartum (PP)] depression. Maternal-to-infant LCP transport during pregnancy and lactation is at the expense of maternal status, a process known as biomagnification. Despite biomagnification, maternal and infant LCP status generally declines during lactation. To assess the 1) turning point of biomagnification [level from which maternal (m)LCP status exceeds infant (i)LCP status]; 2) LCP equilibrium (steady-state-level from which mRBC-LCP stop declining during lactation); 3) corresponding iLCP-status; and 4) the relationship between RBC-DHA and RBC-arachidonic acid (AA), we measured RBC-fatty acids in 193 Tanzanian mother-infant pairs with no, intermediate (2–3 times/wk), and high (4–5 times/wk) freshwater fish consumption at delivery and after 3 mo of exclusive breast-feeding. At 3 mo, mRBC-DHA was lower than the corresponding iRBC-DHA up to a mRBC-DHA of 7.9 g%. mRBC-DHA equilibrium, with equivalent mRBC-DHA at both delivery and at 3 mo PP, occurred at 8.1 g%. This mRBC-DHA equilibrium of 8.1 g% corresponded with an iRBC-DHA of 7.1–7.2 g% at delivery that increased to 8.0 g% at 3 mo. We found between-group differences in mRBC-AA; however, no differences in iRBC-AA were observed at delivery or 3 mo. Relations between RBC-DHA and RBC-AA were bell-shaped. We conclude that, at steady-state LCP intakes during lactation: 1) biomagnification occurs up to 8 g% mRBC-DHA; 2) mRBC-DHA equilibrium is reached at 8 g%; 3) mRBC-DHA equilibrium corresponds with an iRBC-DHA of 7 g% at delivery and 8 g% after 3 mo; 4) unlike RBC-DHA, mRBC-AA and iRBC-AA are independently regulated in these populations; and 5) bell-shaped RBC-DHA vs. RBC-AA-relations might support uniform iRBC-AA. A (maternal) RBC-DHA of 8 g% might be optimal for infant neurodevelopment and adult cardiovascular disease incidence.
机译：长链PUFA（LC-PUFA或LCP）的低消耗与神经发育欠佳，冠状动脉疾病和[产后（PP）]抑郁有关。怀孕和哺乳期间母婴间LCP的运输是以母体身份为代价的，这一过程称为生物放大。尽管进行了生物放大，但母乳LCP的状况在哺乳期通常会下降。评估1）生物放大的转折点[母亲（m）LCP状况超过婴儿（i）LCP状况的水平; 2）LCP平衡（在哺乳期mRBC-LCP停止下降的稳态水平）; 3）相应的iLCP状态;和4）RBC-DHA和RBC-花生四烯酸（AA）之间的关系，我们测量了193对坦桑尼亚母婴对中的RBC-脂肪酸，无，中间（2-3周/周）和高（4-5）次/周）纯水母乳喂养3个月后的淡水鱼消耗量。在3个月时，mRBC-DHA低于相应的iRBC-DHA，直至7.9g％的mRBC-DHA。 mRBC-DHA平衡达到8.1 g％，在分娩时和在3 mo PP时具有相等的mRBC-DHA。该mRBC-DHA平衡为8.1 g％，对应于分娩时iRBC-DHA为7.1–7.2 g％，在3 mo时增加到8.0 g％。我们发现mRBC-AA的组间差异;然而，在分娩或3 mo时，iRBC-AA没有观察到差异。 RBC-DHA和RBC-AA之间的关系呈钟形。我们得出的结论是，泌乳期间处于稳定状态的LCP摄入量：1）生物放大率高达8 g％mRBC-DHA; 2）mRBC-DHA平衡达到8 g％; 3）mRBC-DHA平衡对应于iRBC-DHA在递送时为7g％，在3mo后为8g％; 4）与RBC-DHA不同，mRBC-AA和iRBC-AA在这些人群中受到独立调节; 5）钟形的RBC-DHA与RBC-AA的关系可能支持统一的iRBC-AA。 （母体）RBC-DHA为8 g％对于婴儿神经发育和成人心血管疾病的发生率可能是最佳的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号