Rhinosporidiosis is a chronic granulomatous disease of mucous membranes and is endemic in South India and Sri Lanka. Although it predominantly affects nose and nasopharyngeal mucosa, other sites are also rarely affected. High index of suspicion and characteristic pathological feature are the mainstay of diagnosis for extra nasal infection. We describe a case of 35 year old north Indian male who presented with urethral polyp. Otorhinolaryngological examination revealed a nasal mass as well. Biopsy from both the urethral and nasal mass showed features of rhinosporidiosis. The aetiopathogenesis, clinical & pathological picture and management of the disease have been discussed. Introduction Rhinosporidium seeberi predominantly affects the mucous membranes of the nose and nasopharynx. The organism thrives in hot, tropical climates, and endemic zones are South India and Sri Lanka.1 It occasionally involves the lips, palate, uvula, conjunctiva, larynx, trachea, penis, vagina and bone.2,3 The diagnosis may be delayed when extranasal sites are involved. Occupational history and histopathology are helpful in arriving at a proper diagnosis. Case Report A 35 yr old male resident of Uttar Pradesh, fisherman by occupation presented with a polypoid lesion at the urethral orifice. There was also a history of progressively increasing nasal obstruction on the left side for the past 1yr and spontaneous nasal bleeding for past 6 months. Genital examination showed a polypoidal lesion 1.5 x 1.0x 0.5 cm present at the terminal urethra. Otorhinolaryngologic examination revealed a deep red, sessile, papillomatous lesion arising from lateral wall of right nasal cavity (Fig 1). The friable lesion resembled a strawberry, had yellow spots on undersurface, which bled on manipulation. The patient was subjected to contrast enhanced computerized tomography of nose and paranasal sinuses. Subsequently punch biopsy was performed from penile and nasal mass. Histopathologically the lesion contained unique round body structures of Rhinosporidium seeberi embedded in a fibromyxoid stroma. Diffuse infiltration of lymphocytes, monocytes, and plasma cells was seen (Fig 2).
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机译：鼻孢子虫病是一种慢性肉芽肿性粘膜疾病，在印度南部和斯里兰卡流行。尽管它主要影响鼻子和鼻咽粘膜，但其他部位也很少受到影响。高怀疑度指标和典型病理特征是鼻外感染诊断的主要手段。我们描述了一个35岁的印度北部男性男性患者的尿道息肉病例。耳鼻喉科检查也显示出鼻腔肿物。尿道和鼻腔肿物的活检均表现出鼻孢子虫病的特征。已经讨论了其发病机理，临床和病理特征以及对疾病的处理。引言西伯利亚鼻孢子虫主要影响鼻子和鼻咽的粘膜。该生物体在印度南部和斯里兰卡等热带炎热，热带地区和地方性地区1壮成长。1它偶尔涉及嘴唇，上颚，悬雍垂，结膜，喉，气管，阴茎，阴道和骨骼。2,3诊断可能会延迟。当涉及鼻外部位时。职业病史和组织病理学有助于正确诊断。病例报告北方邦的一名35岁男性居民，按职业划分的渔民在尿道口处出现息肉样病变。在过去的1年中，左侧鼻塞逐渐增多，并且在过去的6个月中自发性鼻出血也有史。生殖器检查显示在尿道末端处有一个1.5 x 1.0 x 0.5 cm的息肉样病变。耳鼻喉科检查发现右鼻腔侧壁出现深红色，无梗，乳头状病变（图1）。易碎的病灶类似于草莓，表面下有黄色斑点，在操作时会出血。该患者接受了鼻子和鼻旁窦的对比增强计算机断层扫描。随后从阴茎和鼻腔肿块进行穿刺活检。从组织病理学上讲，该病灶内嵌有纤维粘胶样基质的独特的圆形球形鼻孢子虫结构。可见淋巴细胞，单核细胞和浆细胞的扩散浸润（图2）。
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