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首页> 外文期刊>The Internet Journal of Tropical Medicine >Usefulness Of New Hematologic Parameters In Hemoglobin Disorders
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Usefulness Of New Hematologic Parameters In Hemoglobin Disorders

机译：新的血液学参数在血红蛋白疾病中的有用性

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Thalassemia and Hemoglobinopathy is the disease transmitted by autosomal recessive genes. The research conducted in Thailand found the prevalence of thalassemia genes in various parts of the country such as ?- thalassemia 1 trait found in Bangkok around 35 %, Chiengmai 12 %. However, the ?- thalassemia 2 trait found a bit lower than the previous ones especially in Bangkok found only 16%, Chiengmai 19% respectively. For ?- thalassemia found in Bangkok 3 % ,meanwhile it was found in Chiengmai 9%, northeastern part 2-3%.Hemoglobin E is one of the prominent abnormal hemoglobin in Thailand and acting itself as ?- thalassemia trait found in Bangkok 13-17%, northeastern part 32-60% .The percentage will be increased because those who carry thalassemia genes move around the country as migrants and get marry finally their offsprings will affect with thalassemia and some of them are silent carriers. This phenomenon will be occurred repeatedly. Nowadays, the ministry of health has set a program so called non infectious diseases control. The control will be useless if there is no effective procedures in identifying carriers.Recently, Technicon has used Flow cytometry combined with the fluorescent staining can categorize reticulocyte into L retic, M retic and H retic and reticulocyte indices such as MCV, CHCM, RDW, HDW, CH and CHDW respectively. We have ever used these parameters in identifying couples who have had their offsprings affected with thalassemia H ( genotype: ?- thalassemia 1/ ?- thalassemia 2). We found that almost all parameters can be used as a tool in identifying ?-thalassemia 1 carriers with significant difference (P<0.05) when compared to normal control group. Unfortunately, ?- thalassemia 2 carriers have only 5 parameters been significant difference when compared to normal control. However, it needs further evaluation in a large number of patients and in other forms of thalassemia , iron deficiency and anemia secondary to chronic diseases.
机译：地中海贫血和血红蛋白病是由常染色体隐性基因传播的疾病。在泰国进行的研究发现，地中海贫血基因在该国各地普遍存在，例如曼谷发现的β-地中海贫血1特质约为35％，清迈约为12％。然而，β-地中海贫血2的性状发现比以前的性状要低一些，特别是在曼谷，分别只有16％，Chiengmai和19％。在曼谷发现3％的地中海贫血，在清迈发现9％，东北部2-3％。 17％，东北地区为32-60％。由于携带地中海贫血基因的人随着移民移居全国并最终结婚，其后代将感染地中海贫血，其中一些是沉默的携带者，因此这一百分比将增加。这种现象将反复发生。如今，卫生部已经制定了一项计划，即所谓的非传染性疾病控制。如果没有有效的程序来鉴定携带者，则对照将毫无用处。最近，Technicon使用流式细胞术结合荧光染色可以将网织红细胞分为L网织，M网织和H网织以及网织红细胞指数，例如MCV，CHCM，RDW， HDW，CH和CHDW。我们曾经使用这些参数来确定其子代感染了地中海贫血H（基因型：β-地中海贫血1 /β-地中海贫血2）的夫妇。我们发现，与正常对照组相比，几乎所有参数都可以用作识别具有明显差异（P <0.05）的β-地中海贫血1携带者的工具。不幸的是，与正常对照组相比，β-地中海贫血2携带者只有5个参数有显着差异。但是，它需要对大量患者以及其他形式的地中海贫血，铁缺乏症和继发于慢性疾病的贫血进行进一步评估。

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