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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model
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Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

机译：磺酰脲类药物集中给药对固定应激模型血糖水平的影响

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摘要

Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. The blood glucose level was measured 30, 60, and 120 min after immobilization stress initiation. We found that intracerebroventricular (i.c.v.) injection with 30 μg of glyburide, glipizide, glimepiride or tolazamide attenuated the increased blood glucose level induced by immobilization stress. Immobilization stress causes an elevation of the blood corticosterone and insulin levels. Sulfonylureas pretreated i.c.v. caused a further elevation of the blood corticosterone level when mice were forced into the stress. In addition, sulfonylureas pretreated i.c.v. alone caused an elevation of the plasma insulin level. Furthermore, immobilization stress-induced insulin level was reduced by i.c.v. pretreated sulfonylureas. Our results suggest that lowering effect of sulfonylureas administered supraspinally against immobilization stress-induced increase of the blood glucose level appears to be primarily mediated via elevation of the plasma insulin level.
机译：磺脲类被广泛用作抗糖尿病药。在本研究中，在ICR小鼠中研究了磺酰脲类超剂量给药对固定应激诱导的血糖水平的影响。小鼠一旦被施加固定压力30分钟，然后返回笼子。固定应激开始后30、60和120分钟测量血糖水平。我们发现脑室内（i.c.v.）注射30μg格列本脲，格列吡嗪，格列美脲或tolazamide可以减轻固定压力引起的血糖水平升高。固定压力导致血液中的皮质酮和胰岛素水平升高。磺脲类药物经静脉内预处理当小鼠被迫承受压力时，会导致血液中皮质酮水平进一步升高。另外，磺脲类药物在静脉内预处理。单独使用会导致血浆胰岛素水平升高。此外，i.c.v降低了固定压力诱导的胰岛素水平。预处理的磺脲类药物。我们的结果表明，磺酰脲类药物超剂量给药对固定化应激诱导的血糖水平升高的降低作用似乎主要是通过血浆胰岛素水平的升高来介导的。

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