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Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population

机译:基质金属肽酶2基因多态性与韩国人群中的肥胖症相关。

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The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on an Illumina BeadStation 500 GX. One hundred and forty two overweight/obese (BMI ≥23) and 145 normal (BMI 18 to
机译:这项研究的目的是确定基质金属肽酶2(MMP2)的单核苷酸多态性(SNP)是否与肥胖有关。 MMP2是一种对基质和非基质蛋白(尤其是基底膜成分)具有蛋白水解活性的酶。为了确定MMP2多态性与超重/肥胖之间的关系,我们在Illumina BeadStation 500 GX上使用金门测定法对MMP2编码区的5个SNP(rs17242319,rs1053605,rs243849,rs2287074和rs10775332)进行了基因分型。一百四十二个超重/肥胖(BMI≥23)和145正常(BMI 18至

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