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首页> 外文期刊>Respiration: International Review of Thoracic Diseases >Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.
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Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.

机译：基质金属蛋白酶-1，-9和-12基因多态性与韩国人群慢性阻塞性肺疾病的风险。

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BACKGROUND: Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. OBJECTIVES: To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. METHODS: The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. RESULTS: Of the 3 polymorphisms studied, only the distribution of the MMP-9 -1562C-->T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45-0.98; p = 0.04). CONCLUSIONS: These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
机译：背景：尽管进行了一些研究来评估基质金属蛋白酶（MMP）基因多态性与慢性阻塞性肺疾病（COPD）的关联，但结果并不一致。目的：研究MMP基因的3个多态性的关联（MMP-1 -1607G-> GG，MMP-9 -1562C-> T和MMP-12 N357S），这些多态性与COPD相关。表型，在韩国人群中有发生COPD的风险。方法：确定301例COPD患者和333例健康对照者的3个基因多态性。结果：在所研究的3个多态性中，病例和对照之间只有MMP-9 -1562C-> T基因型的分布显着不同（p = 0.01），而在患者中，T等位基因变异的频率显着降低。与对照组相比（10.4 vs. 15.7％; p = 0.006）。与具有纯合野生型等位基因的个体相比，具有至少1个变异T等位基因的个体的COPD风险显着降低（校正比值比= 0.69; 95％CI = 0.45-0.98; p = 0.04）。结论：这些发现表明，MMP-9 -1562C-> T多态性可以用作确定韩国人群中COPD遗传易感性的标志物。

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