Oral administration of paraquat perturbs immunoglobulin productivity in mouse

Masaaki Okabe; Sogo Nishimoto; Takuya Sugahara; Koichi Akiyama; Yoshimi Kakinuma

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Oral administration of paraquat perturbs immunoglobulin productivity in mouse

机译：口服百草枯干扰小鼠免疫球蛋白的生产力

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Paraquat is one of the most widely used herbicides in the world and has been known to injure lungs, liver and skin in animals and human. Hence, it is important to understand the manner of paraquat in mammals. We studied the effect of paraquat on the immune function of mouse in vitro and in vivo . When splenocytes were cultured in vitro with various concentrations of paraquat, IgA productivity was not affected while IgG and IgM productivity decreased. On the other hand, Oral administration of paraquat for 1, 2 or 3 weeks increased IgA level but decreased IgM levels in serum of mice. Similarly IgA productivity increased while IgM productivity decreased. These results suggest that paraquat perturbs the lymphocytes immunoglobulin productivity in an immunoglobulin class-dependent manner.

机译：百草枯是世界上使用最广泛的除草剂之一，已知会伤害动物和人类的肺，肝和皮肤。因此，了解百草枯在哺乳动物中的使用方式非常重要。我们研究了百草枯对小鼠体内外免疫功能的影响。当在体外用各种浓度的百草枯培养脾细胞时，IgA生产力不受影响，而IgG和IgM生产力则下降。另一方面，口服百草枯1、2或3周可增加小鼠血清中的IgA水平，但降低IgM水平。同样，IgA生产率提高了，而IgM生产率却下降了。这些结果表明百草枯以免疫球蛋白类依赖性方式干扰淋巴细胞的免疫球蛋白生产力。

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《The Journal of toxicological sciences》 |2010年第2期|共7页
作者
Masaaki Okabe; Sogo Nishimoto; Takuya Sugahara; Koichi Akiyama; Yoshimi Kakinuma;
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中图分类药学;
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1. Oral administration of paraquat perturbs immunoglobulin productivity in mouse [J] . OkabeM., NishimotoS., SugaharaT., The Journal of toxicological sciences . 2010,第2期

机译：口服百草枯干扰小鼠免疫球蛋白的生产力
2. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice. [J] . Oomizu S, Onishi N, Suzuki H, Clinical and experimental allergy : . 2006,第1期

机译：粉状魔芋葡甘露聚糖的口服给药可防止在BALB / c小鼠中注射同种角质形成细胞提取物引起的血浆免疫球蛋白E和免疫球蛋白G水平增加。
3. Oral administration of interferon-alpha induces a transient decline in oral mucosal immunoglobulins and an increase in interleukin-5. [J] . Naylor PH, Naylor CW, Hendrix S, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 1999,第8期

机译：口服干扰素-α诱导口腔粘膜免疫球蛋白的短暂下降和白介素5的上升。
4. Antitumor activity of rice-shochu post-distillation slurry and vinegar produced from the post-distillation slurry via oral administration in a mouse model [C] . Takahiro Seki, Shigeru Morimura, Tohru Shigematsu, International Conference on Food Factors . 2004

机译：水稻沉淀后蒸馏浆料和从蒸馏浆液中由口服给药中的蒸馏浆料和醋的抗肿瘤活性
5. Purification of immunoglobulins, their bonding onto latex particles and the development of latex agglutination test for mouse immunoglobulin-G for monoclonal antibody assessment. [D] . Sompuram, Seshi Reddy. 1987

机译：免疫球蛋白的纯化，它们与乳胶颗粒的键合以及用于小鼠免疫球蛋白-G的乳胶凝集试验的发展，用于单克隆抗体评估。
6. Comparison of the Intraperitoneal Retroorbital and per Oral Routes for F-18 FDG Administration as Effective Alternatives to Intravenous Administration in Mouse Tumor Models Using Small Animal PET/CT Studies [O] . Chulhan Kim, In Hye Kim, Seo-il Kim, 2011

机译：F-18 FDG给药的腹膜内眶后和经口途径的比较作为使用小动物PET / CT研究的小鼠肿瘤模型中静脉给药的有效替代方法
7. Therapy with transcutaneous administration of imiquimod combined with oral administration of sorafenib suppresses renal cell carcinoma growing in an orthotopic mouse model [O] . Takashi Karashima, Keiko Udaka, Mayumi Niimura, 2017

机译：具有过实酰亚胺酮的治疗联合索拉非尼酮的口服给药抑制了在原位小鼠模型中生长的肾细胞癌
8. HMX: Toxicokinetics of (14)C-HMX Following Oral Administration to the Rat and Mouse and Intravenous Administration to the Rat [R] . Cameron, B. D. 1986

机译：HmX：口服给予大鼠和小鼠后的（14）C-HmX的毒代动力学和对大鼠的静脉内给药

Oral administration of paraquat perturbs immunoglobulin productivity in mouse

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