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首页> 外文期刊>The Journal of Veterinary Medical Science >Antibody response to equine coronavirus in horses inoculated with a bovine coronavirus vaccine
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Antibody response to equine coronavirus in horses inoculated with a bovine coronavirus vaccine

机译：接种牛冠状病毒疫苗的马对马冠状病毒的抗体应答

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A vaccine for equine coronavirus (ECoV) is so far unavailable. Bovine coronavirus (BCoV) is antigenically related to ECoV; it is therefore possible that BCoV vaccine will induce antibodies against ECoV in horses. This study investigated antibody response to ECoV in horses inoculated with BCoV vaccine. Virus neutralization tests showed that antibody titers against ECoV increased in all six horses tested at 14 days post inoculation, although the antibody titers were lower against ECoV than against BCoV. This study showed that BCoV vaccine provides horses with antibodies against ECoV to some extent. It is unclear whether antibodies provided by BCoV vaccine are effective against ECoV, and therefore ECoV challenge studies are needed to evaluate efficacy of the vaccine in the future.
机译：迄今为止尚无马冠状病毒疫苗（ECoV）。牛冠状病毒（BCoV）与ECoV抗原相关。因此，BCoV疫苗可能会在马匹中诱导针对ECoV的抗体。这项研究调查了接种BCoV疫苗的马对ECoV的抗体反应。病毒中和测试表明，在接种后14天测试的所有六匹马中，针对ECoV的抗体滴度均增加，尽管针对ECoV的抗体滴度低于针对BCoV的抗体。这项研究表明，BCoV疫苗在一定程度上为马提供了抗ECoV的抗体。目前尚不清楚BCoV疫苗提供的抗体是否对ECoV有效，因此需要进行ECoV攻击研究以评估疫苗的有效性。

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