...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of toxicological sciences >Pyrolysis of UR-144, a synthetic cannabinoid, augments an affinity to human CB1 receptor and cannabimimetic effects in mice
【24h】

Pyrolysis of UR-144, a synthetic cannabinoid, augments an affinity to human CB1 receptor and cannabimimetic effects in mice

机译：合成大麻素UR-144的热解可增强对人CB1受体的亲和力并在小鼠中产生大麻素作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Drug abusers most often smoke ‘herbal incense’ as a cigarette or inhale it using a smoking tool. Smoking may cause pyrolysis of the drug and produce decomposed products of which biological effect has never been investigated. The synthetic cannabinoid UR-144 is known to undergo thermal degradation, giving a ring-opened isomer, so-called UR-144 degradant. The present study demonstrates by using UR-144 as a model drug that the smoke of burned UR-144 contains the UR-144 degradant. The UR-144 degradant showed approximately four fold higher agonist activity to human CB1 receptor and augmented hypothermic and akinetic actions in mice compared to UR-144. These results indicate that smoking behavior may increase psychological actions of the certain synthetic cannabinoids.
机译：吸毒者最经常将“草药香”作为香烟吸烟，或使用吸烟工具将其吸入。吸烟可能引起药物热解，并产生分解产物，其生物学作用从未得到研究。已知合成大麻素UR-144会发生热降解，产生开环异构体，即所谓的UR-144降解剂。本研究通过使用UR-144作为模型药物证明，燃烧的UR-144烟中含有UR-144降解物。与UR-144相比，UR-144降解物对人CB 1 受体的激动剂活性高约四倍，并具有增强的低温和运动功能。这些结果表明，吸烟行为可能会增加某些合成大麻素的心理行为。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号