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首页> 外文期刊>The Journal of toxicological sciences >Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats
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Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

机译：积雪草提取物（CAE）对Sprague-Dawley老年大鼠实验性帕金森病的神经保护作用

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Reactive oxygen species (ROS) play an important role in ageing and age-related neurodegenerative changes including Parkinson’s disease (PD). PD is characterized by signs of major oxidative stress and mitochondrial damage in the pars compacta of the substantia nigra. Present study was designed to investigate whether the Centella asiatica extract (CAE) would prevent 1-methyl-4-phenyl-1,2,3,6 - tetrahydropyridine (MPTP) - induced neurotoxicity in aged Sprague-Dawley rats. Adult, male Sprague-dawley rats of 300-350 g were divided into control, C. asiatica alone, MPTP alone (20 mg/kg, for 21 days) and MPTP with C. asiatica (300 mg/kg for 21 days) groups. Effect of aqueous extract of C. asiatica on oxidative biomarker levels in corpus striatum and hippocampus homogenate was examined. MPTP-challenged rats elicited a significant increase in lipid hydroperoxides (LPO) (p
机译：活性氧（ROS）在衰老和与年龄有关的神经退行性变化（包括帕金森氏病（PD））中起着重要作用。 PD的特征在于黑质致密部中主要的氧化应激和线粒体损伤的迹象。本研究旨在调查积雪草提取物（CAE）是否能预防1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的Sprague-Dawley老龄大鼠神经毒性。将成年雄性Sprague-dawley大鼠300-350 g分为对照组，仅亚洲实蝇，单独的MPTP（20 mg / kg，持续21天）和带有亚洲实蝇的MPTP（300 mg / kg，持续21天）组。检验了亚洲实蝇的水提取物对纹状体和海马匀浆中氧化生物标志物水平的影响。受到MPTP攻击的大鼠引起脂质氢过氧化物（LPO）的显着增加（p

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