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首页> 外文期刊>The Journal of toxicological sciences >Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung
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Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung

机译：扩散活性氧的空气净化器可能会导致肺部DNA损伤

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Several appliance manufacturers have recently released new type air purifiers that can disinfect bacteria, fungi and viruses by diffusing reactive oxygen species (ROS) into the air. In this study, mice were exposed to the outlet air from each of 3 air purifiers from different manufacturers (A, B, C), and the lung was examined for DNA damage, lipid peroxidation and histopathology to confirm the safety of these air purifiers. Neither abnormal behavior during exposure nor gross abnormality at necropsy was observed. No histopathological changes were also observed in the lung. However, significant increase of DNA damage was detected by the comet assay in the lung immediately after the direct exposure for 48 hr to models A and B, and for 16 hr to model B. As for model B, DNA migration was also increased by 2 hr exposure in a 1 m3 plastic chamber but not by 48 hr exposure in a room (12.6 m3). Model C did not cause DNA damage. Lipid peroxidation and 8-hydroxy deoxyguanosine (8-OH-dG) was not increased under the conditions DNA damage was detected by the comet assay. The present results revealed that some models of air purifiers that diffuse ROS potentially cause DNA damage in the lung although the mechanism was left unsolved.
机译：几家家电制造商最近发布了新型空气净化器，该空气净化器可以通过将活性氧（ROS）扩散到空气中来对细菌，真菌和病毒进行消毒。在这项研究中，小鼠暴露于来自不同制造商（A，B，C）的3种空气净化器各自的出口空气中，并检查了肺的DNA损伤，脂质过氧化和组织病理学，以确认这些空气净化器的安全性。既未观察到暴露期间的异常行为，也未观察到尸检时的总体异常。在肺中也未观察到组织病理学变化。然而，在直接暴露于模型A和B 48小时以及暴露于模型B 16小时之后，立即通过肺部彗星试验检测到DNA损伤显着增加。对于模型B，DNA迁移也增加了2在1 m 3 塑料室内进行小时暴露，但不在房间（12.6 m 3 ）中暴露48小时。 C型没有引起DNA损伤。在通过彗星试验检测到DNA损伤的条件下，脂质过氧化和8-羟基脱氧鸟苷（8-OH-dG）没有增加。目前的结果表明，扩散ROS的某些空气净化器模型可能会导致肺部DNA损伤，尽管该机理尚未解决。

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