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首页> 外文期刊>The Journal of the South African Veterinary Association >Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate
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Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate

机译：肌肉内多次注射亚氨基甲酸双丙酸酯对6个健康小马的临床和临床病理变化

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Haematological variables and selected serum indices, particularly those affected by changes in renal and hepatic function, were examined in 6 healthy ponies following 4 intramuscular doses of 4 mg/kg imidocarb dipropionate administered every 72 hours. This treatment regime has been reported to sterilise experimental Babesia equi infections in horses and may have value in preventing the spread of this disease during exportation of possible carrier horses to non-endemic countries. Serum bile acids and serum gamma glutamyltransferase activity were measured to evaluate the effect of this treatment regime on hepatic function. Owing to the absence of any increase in these variables it was concluded that this treatment regime had no clinically detectable deleterious effect on hepatic function in healthy ponies. Urinary gamma glutamyltransferase : creatinine ratios (IU/g), serum creatinine and fractional clearance of sodium, potassium and phosphate (%) were calculated as a measure of renal function. Urinary GGT and urinary GGT : creatinine ratios were significantly elevated on Day 5 of the trial, with 2 of the trial animals also exhibiting mild azotaemia indicative of changes in renal function. The changes in urine GGT : urine creatinine ratios observed in this study also provides evidence of the value of this ratio for the early detection of renal toxicity, following exposure to nephrotoxic agents.
机译：在每72小时注射4毫克4 mg / kg丙二酸亚氨基甲酸二丙酯肌注后，在6个健康小马中检查了血液学变量和选定的血清指标，特别是那些受肾脏和肝功能变化影响的指标。据报道，这种治疗方案可以对马中的实验性巴比斯马感染进行绝育，并且在防止可能的携带者向非流行国家出口马匹中传播这种疾病可能具有价值。测量血清胆汁酸和血清γ-谷氨酰转移酶活性以评估该治疗方案对肝功能的影响。由于这些变量没有任何增加，因此得出结论，该治疗方案对健康小马的肝功能没有临床可检测到的有害作用。计算尿γ-谷氨酰转移酶：肌酐比率（IU / g），血清肌酐和钠，钾和磷酸盐的分数清除率（％），作为衡量肾功能的指标。在试验的第5天，尿GGT和尿GGT：肌酐的比率显着升高，其中2只试验动物还表现出轻度的氮质血症，表明肾脏功能发生了变化。在这项研究中观察到的尿GGT：尿肌酐比率的变化也提供了该比率对暴露于肾毒性药物后早期发现肾毒性的价值的证据。

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