Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intravenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers

Xu Mingzhen; Zhou Ying; Ni Yang; He Xiaomeng; Li Huqun; Sattar Haseeb; Chen Hui; Li Weiyong

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Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intravenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers

机译：健康中国志愿者单次或多次给药后左，硫，舒巴利特口服，肌内和静脉给药的耐受性和药代动力学比较

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摘要

Purpose: The aim of this study was to characterize the pharmacokinetic (PK) properties and assess the safety profiles of different formulations of levosulpiride in healthy Chinese volunteers.

机译：目的：本研究的目的是表征健康中国志愿者的药物动力学（PK）特性并评估左旋磺必利不同制剂的安全性。

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来源
《Clinical therapeutics》 |2015年第11期|共10页
作者
Xu Mingzhen; Zhou Ying; Ni Yang; He Xiaomeng; Li Huqun; Sattar Haseeb; Chen Hui; Li Weiyong;
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正文语种 eng
中图分类治疗学;
关键词
adverse effects; bioavailability; levosulpiride; pharmacokinetics;

机译：不良反应;生物利用度;左旋硫必利;药代动力学;

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1. Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intravenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers [J] . Xu Mingzhen, Zhou Ying, Ni Yang, Clinical therapeutics . 2015,第11期

机译：健康中国志愿者单次或多次给药后左，硫，舒巴利特口服，肌内和静脉给药的耐受性和药代动力学比较
2. Pharmacokinetics and tolerability of febuxostat after oral administration in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose three-way crossover study [J] . Zhou Huili, Zheng Yunliang, Wu Guolan, International journal of clinical pharmacology and therapeutics . 2016,第2期

机译：口服非布索坦在健康中国志愿者中的药代动力学和耐受性：一项随机，开放标签，单剂量和多剂量三效交叉研究
3. Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study [J] . Zhou Huili, Wu Guolan, Hu Xingjiang, Clinical therapeutics . 2015,第6期

机译：中国健康志愿者口服环丙沙星的药代动力学特性和耐受性：一项随机，开放标签，单剂量和多剂量三效交叉研究
4. Pharmacokinetics and Tolerability of Sublingual Fentanyl in Healthy Japanese and Caucasian Volunteers: Phase I, Open-Label Single-Dose Study [C] . U. Lorch, F. Farrell, J. Kilborn, International Pain Clinic Congress . 2008

机译：健康日本和白种人志愿者舌下芬太尼的药代动力学和耐受性：I期，开放标签单剂量研究
5. Tissue Residue Depletion in Domestic Chickens After Multiple Oral and Single Intravenous Dosing of Meloxicam [D] . Dutch, Rachel Simone. 2019

机译：多种口服和单一静脉剂量的美洛昔康后国内鸡组织残留枯萎病
6. Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers [O] . Chuting Gong, Janvier Engelbert Agbokponto, Wen Yang, 2014

机译：一次或多次肌肉注射对中国健康志愿者左氧舒必利的药代动力学
7. Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers [O] . Chuting Gong, Janvier Engelbert Agbokponto, Wen Yang, 2014

机译：中国健康志愿者单次和多次肌肉注射后左旋磺酰胺的药代动力学

Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intravenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers

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