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首页> 外文期刊>The Open Anesthesia Journal >Epidural Clonidine as an Adjuvant to Local Anesthetic in Lower Abdominal and Lower Limb Surgeries: A Randomised Controlled Study
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Epidural Clonidine as an Adjuvant to Local Anesthetic in Lower Abdominal and Lower Limb Surgeries: A Randomised Controlled Study

机译：硬膜外可乐定作为下腹部和下肢手术中局部麻醉的佐剂：一项随机对照研究

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Background:Acute pain leads to adverse physiological and psychological disturbances. Hence, this study was done to evaluate and compare the onset and duration of sensory anesthesia, motor paralysis and duration of analgesia using 0.5% plain bupivacaine, with clonidine (2μg/kg) in patients posted for lower abdominal and lower limb surgeries under epidural anaesthesia.Materials and methods:62 Patients posted for elective lower abdominal, gynaecological and lower limb surgeries under epidural anesthesia, aged 18 to 60 years, height more than 150 cms of ASA physical status 1 or 2 were included. All patients were randomized into two groups of 31 individuals each.Results:Clonidine in the dose of 2μg/kg added to bupivacaine injected into epidural space significantly prolonged the duration of analgesia when compared to bupivacaine alone. No effect on the onset of sensory and motor blockade was observed. However, it increases the duration of motor blockade. Clonidine also has effect on sedation level, pulse rate and mean arterial blood pressure.Conclusion:Clonidine causes increased sedation; fall in pulse rate and mean arterial blood pressure, which however, did not require active intervention in this study.
机译：背景：急性疼痛导致不良的生理和心理障碍。因此，本研究旨在评估和比较硬膜外麻醉下下腹部和下肢手术患者使用0.5％普通布比卡因与可乐定（2μg/ kg）的感觉麻醉，运动麻痹的发作和持续时间，运动麻痹和镇痛持续时间。材料与方法：62例年龄在18至60岁，身高超过150 cms的ASA身体状况为1或2的硬膜外麻醉下下腹部，妇科和下肢手术患者。所有患者随机分为两组，每组31人。结果：与单独使用布比卡因相比，向硬膜外腔注射布比卡因的剂量为2μg/ kg的可乐定显着延长了镇痛时间。没有观察到对感觉和运动阻滞发作的影响。但是，这会增加电机封锁的持续时间。可乐定对镇静水平，脉搏频率和平均动脉血压也有影响。脉率和平均动脉血压的下降，但是，本研究不需要积极干预。

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