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首页> 外文期刊>The Open Crystallography Journal >Metal-Oxicam Coordination Compounds: Structure, Biological Activityand Strategies for Administration
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Metal-Oxicam Coordination Compounds: Structure, Biological Activityand Strategies for Administration

机译：金属-Oxicam配位化合物：结构，生物学活性和管理策略。

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The crystal structures for metal-oxicam compounds published since the year 2000 are listed and commented inthis review. The structural properties are interpreted in order to look for characteristics that might be significant for possiblebiological activities, for innovative strategies aimed to administering the metal based drugs in vivo. The relevant biologicalstudies are also listed and commented. The number of structural reports on metal-oxicam compounds that werepublished up to the year 2000 was five, whereas the number of X-ray structures for the same class of compounds publishedsince then is fifteen. The efforts carried out on the field during the past decade increased much and involved severalresearch groups all over the world. The predominant metal was CuII, but interest on SnIV increased too, whereas the intereston PtII continued for compounds derived from Zeise’s salt. Other metals linked to oxicam ligands were investigated.The X-ray structural studies until ca ten years ago involved metal-piroxicam compounds, only; instead, during these pastten years also metal-meloxicam, -tenoxicam, -isoxicam, and -lornoxicam were studied and reported. The reactivity of cinnoxicamwith copper(II)-acetate was also studied and reported. The coordination arrangement around CuII showed a varietyof modes that include pseudo-octahedral, -square planar, -square pyramidal. The oxicam coordination mode dependson the ligand, the reaction media and experimental conditions. The ligands usually occupy the equatorial positions of thecoordination sphere and assume ZZZ conformations in the case they are in the anionic form (HOXI-).
机译：自2000年以来发布的金属-氧杂环丁烷化合物的晶体结构在本综述中列出并进行了评论。解释结构特性是为了寻找对于可能的生物学活动可能重要的特性，以及旨在体内施用金属基药物的创新策略。相关的生物学研究也被列出和评论。截止到2000年，有关金属-氧杂环丙烷化合物的结构报告共有五篇，而自那时以来，同一类化合物的X射线结构报告数量为十五篇。在过去的十年中，在该领域所做的努力大大增加了，涉及了全世界的几个研究小组。主要金属是CuII，但对SnIV的兴趣也增加了，而对源自Zeise盐的化合物的PtII的兴趣仍在继续。 X射线的结构研究直到大约十年前才涉及金属-吡罗昔康化合物。相反，在过去的十年中，还研究并报道了金属-美洛昔康，-替诺昔康，-异昔康和-氯诺昔康。还研究了肉桂诺昔康与乙酸铜（II）的反应性。 CuII周围的配位排列显示了多种模式，包括伪八面体，-正方形平面，-正方形锥体。奥昔康配位模式取决于配体，反应介质和实验条件。配体通常占据配位球的赤道位置，并且在它们为阴离子形式（HOXI-）的情况下呈现ZZZ构象。

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