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首页> 外文期刊>The Open Complementary Medicine Journal >Hypolipidemic Activity of Extracts from Eriobotrya japonica and Oleaeuropaea, Traditionally Used in the Greco-Arab Medicine in MaintainingHealthy Fat Levels in the Blood
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Hypolipidemic Activity of Extracts from Eriobotrya japonica and Oleaeuropaea, Traditionally Used in the Greco-Arab Medicine in MaintainingHealthy Fat Levels in the Blood

机译：传统用于希腊阿拉伯医学中维持血液中健康脂肪水平的日本沙枣和油橄榄提取物的降血脂活性

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Loquat (Eriobotrya japonica) and olive leaves (Olea europaea) were investigated for their safety, anti-oxidant,and anti-hypercholesterolemic properties. Therefore, a fixed combination of dry extracts of Eriobotrya japonica and Oleaeuropaea was prepared into so called Cholevel tablets and tested for safety and efficacy in vitro and in vivo tests. No signof toxicity (LDH-release) was observed in cultured human fibroblasts incubated with increasing concentrations ofCholevel. Similar results were seen in MTT assay in co-cultures of human hepatocytes and monocytes. In addition, a highlevel of safety was seen in rats with an LD50 of 17.3 g/kg. The extent of Lipid peroxidation in isolated human LDL fractions,rat liver homogenates, and ferrosulphate was substantial at low concentrations of Cholevel. Hypolipidemic propertieswere assessed in a double blinded- randomized clinical study carried out among 41 human volunteers with hyperlipidemiavalues. The volunteers were divided into three groups. They were asked to continue their usual diet and medicationsunchanged and were evaluated for efficacy and tolerability of Cholevel for 3 months. Group 1 included 12 of personswho were at a fixed dose of statins therapy without fully responding to their medications they consumed Choleveltablets 1 x 3 daily. Group 2 included 20 volunteers who consumed only Cholevel tablets 1 x 3 daily. Group 3 (controlgroup) included 9 volunteers who consumed placebo tablets 1 x 3 daily. Cholevel was well tolerated by all subjects and noside effects were reported. Cholesterol levels were significantly reduced in groups 1 and 2 by 24% and 14.3% after threemonths of Cholevel consumption, respectively. Parallel reductions in both LDL and triglycerides levels and increments inHDL levels were observed. Taken together, results demonstrate safety, tolerability and efficacy of Cholevel that seems tohave dual inhibition on both the absorption and production of cholesterol.
机译：研究了qua（Eriobotrya japonica）和橄榄叶（Olea europaea）的安全性，抗氧化剂和抗高胆固醇血症特性。因此，将日本堇（Eriobotrya japonica）和橄榄木（Oleaeuropaea）的干提取物的固定组合制成所谓的Cholevel片剂，并在体外和体内测试中测试其安全性和有效性。在培养的人成纤维细胞中以升高的Cholevel浓度孵育时，未观察到毒性迹象（LDH释放）。在人肝细胞和单核细胞的共培养物中的MTT测定中观察到相似的结果。另外，在LD50为17.3 g / kg的大鼠中观察到高安全性。在低水平的胆固醇水平下，分离的人LDL组分，大鼠肝匀浆和亚硫酸铁中脂质的过氧化程度很大。在41名高脂血症值的人类志愿者中进行的双盲随机临床研究中评估了降血脂特性。志愿者分为三组。他们被要求继续日常饮食和换药，并评估其3个月的Cholevel疗效和耐受性。第一组包括12人，他们接受固定剂量的他汀类药物治疗，但对他们的药物没有完全反应，他们每天服用1 x 3的Choleveltablets。第2组包括20名志愿者，他们每天仅服用1 x 3的Cholevel片剂。第3组（对照组）包括9名志愿者，他们每天服用1 x 3的安慰剂片剂。所有受试者对胆碱的耐受性良好，且无副作用报告。服用胆固醇三个月后，第1组和第2组的胆固醇水平分别显着降低了24％和14.3％。观察到LDL和甘油三酸酯水平平行降低，HDL水平升高。两者合计，结果表明Cholevel的安全性，耐受性和功效似乎对胆固醇的吸收和产生均具有双重抑制作用。

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