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首页> 外文期刊>The Open Complementary Medicine Journal >A Comparison of Antinociceptive Activity of Mycelial Extract from ThreeSpecies of Fungi of Basidiomycetes
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A Comparison of Antinociceptive Activity of Mycelial Extract from ThreeSpecies of Fungi of Basidiomycetes

机译：三种担子菌真菌菌丝体提取物的抗伤害感受活性比较

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摘要

The antinociceptive activity of mycelial extract from fermented mushroom of Ganoderma lucidum, Coprinuscomatus and Grifola frondosa were studied in this paper. The writhing test, formalin test and hot-plate test were used toevaluate the antinociceptive activity of the acetone extracts of the three Species of Fungi of Basidiomycetes in the studyrespectively. The extract of Ganoderma lucidum inhibited in a dose-dependent manner the acetic acid-induced abdominalconstrictions in mice (p<0.05). Also both phases of the response were significantly inhibited in the formalin test (p<0.05).In the hot-plate test, results showed that extract of Ganoderma lucidum significantly inhibited the reaction time to thermalstimuli at 30, 60, and 90 min (p<0.05). The preliminary toxicologic study demonstrated the safety of it. However the extractfrom fermented mushroom of Coprinus comatus and Grifola frondosa did not show significantly expectative antinociceptiveeffect. Our results show the acetone extract of Ganoderma lucidum is a potent analgesic drug.
机译：本文研究了灵芝，鸡腿菇和灰树菇发酵菌丝体提取物的抗伤害作用。用扭体试验，福尔马林试验和热板试验分别评价了三种担子菌真菌丙酮提取物的抗伤害感受活性。灵芝提取物以剂量依赖性方式抑制乙酸诱导的小鼠腹部收缩（p <0.05）。在福尔马林试验中，反应的两个阶段也均被显着抑制（p <0.05）。在热板试验中，结果表明灵芝提取物在30、60和90分钟时显着抑制了对热刺激的反应时间（p <0.05）。初步的毒理学研究证明了它的安全性。然而，鸡腿菇和蘑菇Grifola frondosa的发酵蘑菇提取物未显示出显着的预期抗伤害感受作用。我们的结果表明，灵芝的丙酮提取物是一种有效的镇痛药。

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