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首页> 外文期刊>The Open Infectious Diseases Journal >A Large Hospital Outbreak of Klebsiella pneumoniae (DHA-1 and SHV-11 Positive): Importance of Detection and Treatment of ampC β-Lactamases
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A Large Hospital Outbreak of Klebsiella pneumoniae (DHA-1 and SHV-11 Positive): Importance of Detection and Treatment of ampC β-Lactamases

机译：大规模的肺炎克雷伯菌爆发（DHA-1和SHV-11阳性）：ampCβ-内酰胺酶检测和治疗的重要性

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摘要

Plasmid-borne ampC β-lactamases are emerging worldwide. There is no gold standard in detecting them so it ispresumed their prevalence is underestimated. They may confer resistance to broad-spectrum cephalosporins. In this paperthe first outbreak in Europe of a Klebsiella pneumoniae harbouring a plasmid-borne DHA-1 β-lactamase and a SHV-11 β-lactamase is reported. Following CLSI (Clinical Laboratories Standards Institute) guidelines the majority of isolateswould have been reported susceptible to third generation cephalosporines in spite of increased MIC values. No failureswere observed in patients treated with cefepime or meropenem. Infections were linked to stay on the intensive care unitand/or urological interventions. The outbreak was stopped after a meeting was organised between the department ofinfection control of the hospital and the complete ICU and urology staff in which the importance of strict hand hygiene tolimit transmission was stressed.
机译：质粒携带的ampCβ-内酰胺酶正在世界范围内出现。检测它们没有黄金标准，因此可以认为它们的流行率被低估了。它们可能赋予对广谱头孢菌素的抗药性。本文报道了在欧洲首次爆发的肺炎克雷伯氏菌，它携带由质粒携带的DHA-1β-内酰胺酶和SHV-11β-内酰胺酶。遵循CLSI（临床实验室标准协会）的指导原则，尽管MIC值增加，但据报道大多数分离株仍对第三代头孢菌素敏感。用头孢吡肟或美罗培南治疗的患者未见失败。感染与留在重症监护病房和/或泌尿科干预有关。在医院的感染控制部门与完整的ICU和泌尿科工作人员之间组织了一次会议之后，爆发停止了，在会议中强调了严格的手部卫生对限制传播的重要性。

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