Complex-Induced Proximity Effect in Lithiation: Unveiling RecentPotentials in Organic Synthesis of Biologically Relevant HeterocyclicCompounds

Olayinka O.Ajani; Michael O. Shomade; AbiolaEdobor-Osoh; Christiana O.Ajanaku; Alice O.Ajani

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Complex-Induced Proximity Effect in Lithiation: Unveiling RecentPotentials in Organic Synthesis of Biologically Relevant HeterocyclicCompounds

机译：复杂化在锂化中的邻近效应：揭示生物相关杂环化合物有机合成中的最新潜力

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Reactions that convert carbon–hydrogen (C–H) bonds into carbon–carbon (C–C) or carbon–heteroatom (C–Y)bonds are attractive tools for organic chemists, potentially expediting the synthesis of target molecules via functionalgroup interconversion. More explorative studies have shown Complex Induced Proximity Effect (CIPE) to be a solutionproviderfor the synthesis of bioactive compounds. This might act as excellent pathfinders to new drugs for combatingmicroorganisms’ resistance challenges to old existing drug. So, a constant review into CIPE and lithiation chemistry iscrucial because they offer excellent pathways to new heterocyclic compounds which are essential agents in drug designand discovery.

机译：将碳氢键（C–H）转换为碳碳键（C–C）或碳–杂原子（C–Y）的反应对于有机化学家来说是有吸引力的工具，可能通过官能团互变加快目标分子的合成。更多的探索性研究表明，复杂诱导邻近效应（CIPE）是生物活性化合物合成的解决方案提供者。这可能是抗击微生物对现有药物的抗药性挑战的新药的极佳探路者。因此，不断审查CIPE和锂化化学是至关重要的，因为它们为新的杂环化合物（在药物设计和发现中必不可少的试剂）提供了绝佳的途径。

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《The Open Organic Chemistry Journal》 |2015年第1期|共19页
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Olayinka O.Ajani; Michael O. Shomade; AbiolaEdobor-Osoh; Christiana O.Ajanaku; Alice O.Ajani;
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中图分类有机化学;
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1. Complex-induced proximity effect in the regioselective lithiation of pyridine derivatives [J] . Dhau J.S., Singh A., Kasetti Y., European journal of organic chemistry . 2012,第9期

机译：吡啶衍生物的区域选择性锂化中的复合物诱导的邻近效应
2. Complex-Induced Proximity Effects. Temperature-Dependent Regiochemical Diversity in Lithiation-Electrophilic Substitution Reactions of N-BOC-2-Azabicyclo[2.1.1]hexane. 2,4- and 3,5-Methanoprolines [J] . Grant R. Krow, Seth B. Herzon, Guoliang Lin, Organic letters . 2002,第18期

机译：复杂引起的邻近效应。 N-BOC-2-氮杂双环[2.1.1]己烷的锂-亲电子取代反应中随温度变化的区域化学多样性。 2,4-和3,5-甲基脯氨酸
3. Complex-Induced Proximity Effects: Evidence for a Prelithiation Complex and a Rate-Determining Deprotonation in the Asymmetric Lithiation of Boc-Pyrrolidine by an i-PrLi/(-)-Sparteine Complex [J] . Donald J. Gallagher, Peter Beak The Journal of Organic Chemistry . 1995,第22期

机译：络合物诱导的邻近效应：i-PrLi /（-）-Sparteine络合物在Boc-吡咯烷的不对称锂化中的预锂化络合物和速率确定的去质子化的证据
4. Oxidation of Organic Compounds by Phenyliodine Diacetate (PhI(OAc)2) as an Eco-Friendly Reagent in the Presence of Manganese Porphyrins as Biologically Relevant Catalysts [C] . Gholamreza Karimipour 2011 2nd International Conference on Chemistry and Chemical Engineering . 2011

机译：锰卟啉作为生物相关催化剂时，苯乙酸碘二乙酸酯（PhI（OAc）2）作为一种生态友好的试剂氧化有机化合物
5. I. Microwave-influenced diversity-oriented synthesis of biologically relevant small and natural-product-like molecules via multicomponent coupling reactions. II. Synthetic studies toward the total synthesis of the repeating tetrasaccharide unit of zwitterionic polysaccharide PS A1. [D] . Santra, Soumava. 2010

机译：I.通过多组分偶联反应，微波影响生物相关的小分子和天然产物样分子的面向多样性的合成。二。对两性离子多糖PS A1的重复四糖单元进行全合成的合成研究。
6. Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations [O] . Rachel Trammell, Khashayar Rajabimoghadam, Isaac Garcia-Bosch -1

机译：铜促进有机分子的功能化：从生物学相关的Cu / O2模型系统到有机金属转化
7. Complex-Induced Proximity Effect in Lithiation: Unveiling RecentudPotentials in Organic Synthesis of Biologically Relevant HeterocyclicudCompounds [O] . Ajani Olayinka O., Shomade M.O, Edobor-Osoh A., 2015

机译：复杂化在锂化中的邻近效应：揭示最近 ud具有生物相关性的杂环 ud的有机合成潜力化合物
8. Inorganic concepts relevant to metal binding, activity, and toxicity in a biological system. [R] . Hoeschele, J. D., Turner, J. E., England, M. W. 1990

机译：与生物系统中的金属结合，活性和毒性相关的无机概念。

Complex-Induced Proximity Effect in Lithiation: Unveiling RecentPotentials in Organic Synthesis of Biologically Relevant HeterocyclicCompounds

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