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首页> 外文期刊>Therapeutic advances in cardiovascular disease. >Patency of the arterial pedal–plantar arch in patients with chronic kidney disease or diabetes mellitus
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Patency of the arterial pedal–plantar arch in patients with chronic kidney disease or diabetes mellitus

机译：慢性肾脏疾病或糖尿病患者的动脉踏板-足底弓通畅

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Patency of the pedal-plantar arch limits risk of amputation in peripheral artery disease (PAD). We examined patients without chronic kidney disease (CKD)/diabetes mellits (DM) [PAD-control], those with DM without CKD, and those with CKD without DM. Uni- and multivariate logistic regression was used to assess association of CKD with loss of patency of the pedal–plantar arch and presence of tibial or peroneal vessel occlusion. Multivariate models adjusted for age, sex, hypertension, hyperlipidemia and smoking. A total of 419 patients were included [age 75.2 ± 10.3 years, 288 (69%) male]. CKD nearly doubled the unadjusted odds ratio (OR) for loss of patency of the pedal–plantar arch. After adjustment, association remained significant for severe CKD [estimated glomerular filtration rate (eGFR) ≤ 29 ml/min compared with eGFR ≥ 60 ml/min, adjusted (adj.) OR 8.24 (95% confidence interval {CI} 0.99–68.36, p = 0.05)]. CKD was not related to risk of tibial or peroneal artery occlusion [PAD-control versus CKD, adj. OR 1.09 (95% CI 0.49–2.44, p = 0.83)] in contrast to DM [PAD–control versus DM, adj. OR 2.41 (95% CI 1.23–4.72, p = 0.01), CKD versus DM, adj. OR 2.21 (95% CI 0.93–5.22); p = 0.07)]. Below the knee (BTK) vascular pattern differs in patients with either DM or CKD alone. Severe CKD is a risk factor for loss of patency of the pedal–plantar arch.
机译：脚掌-弓的通畅限制了外周动脉疾病（PAD）截肢的风险。我们检查了无慢性肾脏疾病（CKD）/糖尿病症状（DM）[PAD-control]，无CKD DM的患者和无DM CKD的患者。单因素和多因素logistic回归用于评估CKD与踏板-足弓通畅性丧失和胫骨或腓骨血管闭塞的相关性。根据年龄，性别，高血压，高脂血症和吸烟对多元模型进行调整。总共包括419名患者[年龄75.2±10.3岁，288名（69％）男性]。 CKD几乎使未调整的比值比（OR）增加了一倍，以消除踏板-足弓的通畅性。调整后，严重CKD [估计的肾小球滤过率（eGFR）≤29 ml / min，而eGFR≥60 ml / min，调整后的（调整的）OR 8.24（95％置信区间{CI} 0.99-68.36， p = 0.05）]。 CKD与胫骨或腓动脉闭塞的风险无关[PAD-control vs CKD，adj。与DM相比，OR为1.09（95％CI 0.49–2.44，p = 0.83）[PAD-control vs DM，adj。或2.41（95％CI 1.23–4.72，p = 0.01），CKD对DM，可调整。或2.21（95％CI 0.93-5.22）; p = 0.07）]。单独患有DM或CKD的患者，膝盖以下（BTK）的血管形态不同。严重的CKD是脚踏板-足弓通畅性丧失的危险因素。

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