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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study
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Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study

机译：补充维生素D对健康参与者心血管疾病危险因素和运动表现的影响：随机安慰剂对照的初步研究

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Evidence suggests associations between vitamin D deficiency and cardiovascular disease (CVD) risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may impact exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance. A randomized placebo-controlled single-blinded parallel trial was conducted in healthy participants (n = 15). They received 2000 IU (50 μg) vitamin D3 per day (n = 9) or placebo (lactose) (n = 6) for 14 days. Body composition, systolic blood pressure (SBP), diastolic blood pressure (DBP) and arterial elasticity (as measured by pulse wave velocity, PWV) were recorded at baseline, day 7 and day 14 of intervention. A total of two 24-hour urine samples were collected to estimate free cortisol and cortisone levels. Exercise performance was assessed at the baseline and day 14 of the intervention using a bike ergometer in which BP and PWV were measured before and after exercise. The distance cycled in 20 minutes and the Borg Scale rate of perceived exertion (RPE) were recorded. In the intervention arm, at day 14, vitamin D supplementation significantly reduced SBP and DBP from 115.8 ± 17.1 and 75.4 ± 10.3 at baseline to 106.3 ± 10.9 (p = 0.022) and 68.5 ± 10.1 mmHg (p = 0.012) respectively. Also arterial stiffness was markedly reduced in the vitamin D group (from 7.45 ± 1.55 to 6.11 ± 1.89, p = 0.049). Urinary free cortisol levels and cortisol/cortisone ratio were significantly reduced from 162.65 ± 58.9 nmol/day and 2.22 ± 0.7 to 96.4 ± 37.2 (p = 0.029) and 1.04 ± 0.4 (p = 0.017) respectively. Exercise-induced SBP and DBP were significantly reduced post vitamin D intake from 130.7 ± 12.2 to 116.1 ± 8.1 (p = 0.012) and from 76.2 ± 8.4 to 70.5 ± 7.7 mmHg (p = 0.042) respectively. The distance cycled in 20 minutes significantly increased from 4.98 ± 2.65 to 6.51 ± 2.28km (p = 0.020), while the Borg Scale RPE reduced from 5.13 ± 1.36 to 4.25 ± 0.71 RPE (p = 0.021). In the placebo arm, no significant effects on CVD risk factors and exercise performance were observed. These results suggest that daily vitamin D supplementation may ameliorate CVD risk factors including a decrease in 11β-HSD1 activity, as evidenced by the decrease in the cortisol/cortisone ratio, and improve exercise performance in healthy individuals. However, large scale studies are required to verify our findings.
机译：有证据表明，维生素D缺乏与心血管疾病（CVD）危险因素之间存在关联，包括高血压和皮质醇水平过高。此外，维生素D含量可能会影响运动表现。因此，我们旨在研究维生素D摄入量对心血管危险因素，游离尿皮质醇和运动表现的影响。在健康参与者中进行了一项随机安慰剂对照的单盲平行试验（n = 15）。他们每天接受2000 IU（50μg）维生素D3（n = 9）或安慰剂（乳糖）（n = 6）14天。在基线，干预的第7天和第14天记录身体成分，收缩压（SBP），舒张压（DBP）和动脉弹性（通过脉搏波速度，PWV测量）。总共收集了两个24小时尿液样本，以估算游离皮质醇和可的松的水平。在干预的基线和第14天使用自行车测功机评估运动表现，其中在运动前后分别测量BP和PWV。记录20分钟内的骑行距离和博格标度的劳累率（RPE）。在第14天的干预组中，补充维生素D可使SBP和DBP分别从基线的115.8±17.1和75.4±10.3分别降低至基线的106.3±10.9（p = 0.022）和68.5±10.1 mmHg（p = 0.012）。维生素D组的动脉僵硬度也显着降低（从7.45±1.55降低至6.11±1.89，p = 0.049）。尿中游离皮质醇水平和皮质醇/可的松比率分别从162.65±58.9 nmol /天和2.22±0.7降至96.4±37.2（p = 0.029）和1.04±0.4（p = 0.017）。运动引起的SBP和DBP维生素D摄入量显着降低，分别从130.7±12.2降至116.1±8.1（p = 0.012）和从76.2±8.4降至70.5±7.7 mmHg（p = 0.042）。 20分钟内骑行的距离从4.98±2.65 km显着增加到6.51±2.28 km（p = 0.020），而博格尺度RPE从5.13±1.36减小到4.25±0.71 RPE（p = 0.021）。在安慰剂组中，未观察到对CVD危险因素和运动表现的显着影响。这些结果表明，每天补充维生素D可以改善CVD危险因素，包括11β-HSD1活性降低（如皮质醇/可的松比例降低所证明），并改善健康个体的运动表现。但是，需要进行大规模研究以验证我们的发现。

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