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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature
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Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature

机译：高血浆甘油三酸酯相关性急性胰腺炎的治疗性血浆置换：病例系列和文献综述

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Severe hypertriglyceridemia (HTG) is the third leading cause of acute pancreatitis (AP) in the United States. The current standard of care includes management of HTG using pharmacological therapy. More recently, plasmapheresis has been proposed as a therapeutic tool for decreasing triglyceride (TG) levels, especially in critically ill patients. Few studies are available to ascertain overall benefits of plasmapheresis over traditional management. To analyze the outcomes of patients treated with plasmapheresis for severe HTG-associated pancreatitis. We conducted a retrospective chart review of three patients with severe HTG- associated (TGs greater than 1000 mg/dl; 11.29 mmol/l) AP at the Methodist University Hospital. All the patients underwent plasmapheresis as part of their treatment. The average TG level before plasmapheresis was 3532 mg/dl (range: 2524–4562 mg/dl; 39.9 mmol/l; range: 28.5–51.6 mmol/l). All patients made a full recovery, with a significant improvement in TG levels after plasmapheresis. The mean number of sessions was 1.3 (range 1–2), and mean TG level after plasmapheresis was 1051 mg/dl (range: 509–1771 mg/dl; 11.9 mmol/l; range: 5.8–20 mmol/l). After the first session, the average reduction of TG level was 2481 mg/dl (range 753–3750 mg/dl; 28 mmol/l; range: 8.5–42.4 mmol/l) or approximately 70%. None of the patients developed complications related to plasmapheresis. Plasmapheresis can be an effective and rapid treatment option in patients with severe HTG and complications. However, further research, including randomized controlled studies, is necessary.
机译：严重的高甘油三酸酯血症（HTG）是美国急性胰腺炎（AP）的第三个主要原因。当前的护理标准包括使用药理疗法治疗HTG。最近，血浆置换术已被提出作为降低甘油三酸酯（TG）水平的治疗工具，特别是在危重患者中。很少有研究能够确定血浆置换术相对于传统治疗的总体益处。分析血浆血浆置换治疗严重HTG相关性胰腺炎患者的结局。我们在卫理公会大学医院对3例严重HTG相关（TG大于1000 mg / dl; 11.29 mmol / l）AP的患者进行了回顾性图表回顾。所有患者均接受血浆置换术作为治疗的一部分。血浆去除前的平均TG水平为3532 mg / dl（范围：2524–4562 mg / dl; 39.9 mmol / l;范围：28.5–51.6 mmol / l）。所有患者均完全康复，血浆置换后TG水平显着改善。平均疗程数为1.3（1-2），血浆置换后的平均TG水平为1051 mg / dl（范围：509-1771 mg / dl; 11.9 mmol / l;范围：5.8-20 mmol / l）。在第一阶段之后，TG水平的平均降低为2481 mg / dl（范围753–3750 mg / dl; 28 mmol / l;范围：8.5–42.4 mmol / l）或大约70％。没有患者发生与血浆置换有关的并发症。血浆置换术可用于重度HTG和并发症的患者的快速有效治疗选择。但是，还需要进一步的研究，包括随机对照研究。

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