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首页> 外文期刊>The open biotechnology journal >Epigenetic Reprogramming in the Mammalian Germ Line: Possible Effects by Endocrine Disruptors on Primordial Germ Cells
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Epigenetic Reprogramming in the Mammalian Germ Line: Possible Effects by Endocrine Disruptors on Primordial Germ Cells

机译：哺乳动物生殖系中的表观遗传重编程：内分泌干扰物对原始生殖细胞的可能影响

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摘要

The present work provides a brief review about evidence obtained in the past years mainly in our laboratory using the mouse model, that germ cells and gonadal somatic cells may be direct target of endocrine disruptors (EDs) from very early stages of gonad formation. Since it is now known that epigenetic pathways are crucial for germline development and that EDs are also able to interfere with epigenetic mechanisms, we will discuss these results mostly in light of possible effects by such molecules on the epigenoma of the primordial germ cells (PGCs), the precursors of the adult gametes that transmit genetic information between generations.
机译：目前的工作简要回顾了过去几年主要在我们实验室中使用小鼠模型获得的证据，即生殖细胞和性腺体细胞可能是性腺形成初期的内分泌干扰物（ED）的直接靶标。既然现在知道表观遗传途径对于种系发育至关重要，并且EDs也能够干扰表观遗传机制，我们将主要根据此类分子对原始生殖细胞（PGCs）表观瘤的可能作用来讨论这些结果。是成年配子的前体，它们在世代之间传递遗传信息。

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