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首页> 外文期刊>Toxins >Ameliorative Effects of Grape Seed Proanthocyanidin Extract on Growth Performance, Immune Function, Antioxidant Capacity, Biochemical Constituents, Liver Histopathology and Aflatoxin Residues in Broilers Exposed to Aflatoxin B 1
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Ameliorative Effects of Grape Seed Proanthocyanidin Extract on Growth Performance, Immune Function, Antioxidant Capacity, Biochemical Constituents, Liver Histopathology and Aflatoxin Residues in Broilers Exposed to Aflatoxin B 1

机译：葡萄籽原花青素提取物对黄曲霉毒素B 1肉仔鸡生长性能，免疫功能，抗氧化能力，生化成分，肝脏组织病理学和黄曲霉毒素残留的改善作用。

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Aflatoxicosis is a grave threat to the poultry industry. Dietary supplementation with antioxidants showed a great potential in enhancing the immune system; hence, protecting animals against aflatoxin B 1 -induced toxicity. Grape seed proanthocyanidin extract (GSPE) one of the most well-known and powerful antioxidants. Therefore, the purpose of this research was to investigate the effectiveness of GSPE in the detoxification of AFB 1 in broilers. A total of 300 one-day-old Cobb chicks were randomly allocated into five treatments of six replicates (10 birds per replicate), fed ad libitum for four weeks with the following dietary treatments: 1. Basal diet (control); 2. Basal diet + 1 mg/kg AFB 1 contaminated corn (AFB 1 ); 3. Basal diet + GSPE 250 mg/kg; (GSPE 250 mg/kg) 4. Basal diet + AFB 1 (1 mg/kg) + GSPE 250 mg/kg; (AFB 1 + GSPE 250 mg/kg) 5. Basal diet + AFB 1 (1mg/kg) + GSPE 500 mg/kg, (AFB 1 + GSPE 500 mg/kg). When compared with the control group, feeding broilers with AFB 1 alone significantly reduced growth performance, serum immunoglobulin contents, negatively altered serum biochemical contents, and enzyme activities, and induced histopathological lesion in the liver. In addition, AFB 1 significantly increased malondialdehyde content and decreased total superoxide dismutase, catalase, glutathione peroxide, glutathione-S transferase, glutathione reductase activities, and glutathione concentration within the liver and serum. The supplementation of GSPE (250 and 500 mg/kg) to AFB 1 contaminated diet reduced AFB 1 residue in the liver and significantly mitigated AFB 1 negative effects. From these results, it can be concluded that dietary supplementation of GSPE has protective effects against aflatoxicosis caused by AFB 1 in broiler chickens.
机译：黄曲霉毒素病是对家禽业的严重威胁。膳食中添加抗氧化剂显示出增强免疫系统的巨大潜力。因此，保护​​动物免受黄曲霉毒素B 1诱导的毒性。葡萄籽原花青素提取物（GSPE）是最著名和最强大的抗氧化剂之一。因此，本研究的目的是研究GSPE对肉鸡AFB 1排毒的有效性。总共将300只1日龄的Cobb小鸡随机分配到五种处理中，每组六只重复（每只重复10只鸡），并通过以下饮食治疗随意喂养四周：1.基础饮食（对照）; 2.基础饮食+ 1 mg / kg被AFB 1污染的玉米（AFB 1）; 3.基础饮食+ GSPE 250 mg / kg; （GSPE 250 mg / kg）4.基础饮食+ AFB 1（1 mg / kg）+ GSPE 250 mg / kg; （AFB 1 + GSPE 250 mg / kg）5.基础饮食+ AFB 1（1mg / kg）+ GSPE 500 mg / kg，（AFB 1 + GSPE 500 mg / kg）。与对照组相比，单独饲喂AFB 1的肉鸡会显着降低生长性能，血清免疫球蛋白含量，血清生化含量和酶活性产生负面变化，并在肝脏中诱发组织病理学病变。此外，AFB 1显着增加了丙二醛含量，并降低了肝脏和血清中的总超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物，谷胱甘肽S转移酶，谷胱甘肽还原酶活性以及谷胱甘肽浓度。在受AFB 1污染的饮食中添加GSPE（250和500 mg / kg）可减少肝脏中AFB 1的残留，并显着减轻AFB 1的负面影响。从这些结果可以得出结论，日粮中添加GSPE对肉鸡AFB 1引起的黄萎病具有保护作用。

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