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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Expressions and clinic significance of miRNA-143, miRNA- 34A, miRNA-944, miRNA-101 and miRNA-218 in cervical cancer tissues
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Expressions and clinic significance of miRNA-143, miRNA- 34A, miRNA-944, miRNA-101 and miRNA-218 in cervical cancer tissues

机译：miRNA-143，miRNA-34A，miRNA-944，miRNA-101和miRNA-218在宫颈癌组织中的表达及其临床意义

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Purpose: To search for novel biomarkers for early diagnosis of cervical cancer, as well as novel therapeutic target for cervical cancer. Methods: A total of 96 cervical tissue specimens were collected from patients in the Second Affiliated Hospital of Zhengzhou University, out of which 10 were normal control. The remaining specimens (86) were cervical cancer specimens and were divided into 4 groups (A - D) based on tumor-biomarker levels of CA125 and SCC. Quantitative real-time polymerase chain reaction technology (qRT-PCR) was used to detect the expressions of miRNA-143, miRNA-34A, miRNA-944, miRNA-101 and miRNA-218 in the cervical cancer tissues. Results: The levels of CA125 (U/mL) and SCC (ug/L) expressed in normal control group and groups A - D were 11.75 and 0.73 (n = 10), 382 and 2.72 (n = 25), 912.9 and 3.93 (n = 21), 1675 and 5.87 (n = 29), and 2120 and 6.66 (n = 11), respectively. Furthermore, qRT-PCR results showed that the expressions of miRNA-944 and miRNA-218 in cervical cancer tissues were markedly up-regulated compared to normal control tissues (p Conclusion: The biomarkers, miRNA-143, miRNA-34A, miRNA-944, miRNA-101 and miRNA-218, can be considered novel for early diagnosis of cervical cancer.
机译：目的：寻找可早期诊断宫颈癌的新型生物标志物以及宫颈癌的新型治疗靶标。方法：收集郑州大学第二附属医院患者的96份宫颈组织标本，其中10份为正常对照。其余标本（86）是宫颈癌标本，根据CA125和SCC的肿瘤生物标志物水平分为4组（A-D）。实时定量聚合酶链反应技术（qRT-PCR）用于检测miRNA-143，miRNA-34A，miRNA-944，miRNA-101和miRNA-218在宫颈癌组织中的表达。结果：正常对照组和AD组的CA125（U / mL）和SCC（ug / L）表达水平分别为11.75和0.73（n = 10），382和2.72（n = 25），912.9和3.93 （n = 21），1675和5.87（n = 29），以及2120和6.66（n = 11）。此外，qRT-PCR结果显示，与正常对照组织相比，宫颈癌组织中的miRNA-944和miRNA-218的表达明显上调（p结论：生物标志物，miRNA-143，miRNA-34A，miRNA-944 miRNA-101和miRNA-218，可以被认为是宫颈癌早期诊断的新方法。

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