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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Preparation, Characterization and Antibacterial Properties of Silver-Chitosan Nanocomposites Using Different Molecular Weight Grades of Chitosan
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Preparation, Characterization and Antibacterial Properties of Silver-Chitosan Nanocomposites Using Different Molecular Weight Grades of Chitosan

机译：不同分子量等级的壳聚糖银-壳聚糖纳米复合材料的制备，表征和抗菌性能

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Purpose: To study the effect of chitosan molecular weight on the physicochemical and antibacterial properties of silver-chitosan nanoparticles. Methods: A series of silver-chitosan nanoparticles of different sizes were produced using various molecular weight (MW) grades of chitosan by an aqueous chemical reduction method. The nanoparticles were characterized by ultraviolet-visible absorption spectroscopy (UV-Vis), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), dynamic light scattering (DLS) and laser Doppler electrophoresis (LDE). The antibacterial properties of the nanoparticles were also evaluated by agar diffusion method. Results: The size of the silver-chitosan nanoparticles, ranging from 21.9 to 175.3 nm, was influenced by chitosan MW as well as by other process conditions. Although, the nanoparticles were not stable in liquid form, they however showed good stability in the solid state due to their low zeta potential. SEM images indicate that the nanoparticles were spherical. The antibacterial activity of the nanoparticles against Staphylococcus aureus increased with decrease in particle size owing to increase in surface area. The smallest particle size (21.9 nm) was obtained by using high chitosan MW at 4 °C and a stirring speed of 800 rpm. Conclusion: Chitosan is an effective agent for the preparation of silver nanoparticles. The size of the nanoparticles can be modulated by varying both chitosan MW and process conditions such as temperature and stirring speed.
机译：目的：研究壳聚糖分子量对银-壳聚糖纳米粒子理化性质和抗菌性能的影响。方法：通过水化学还原法，使用不同分子量（MW）的壳聚糖，制备了一系列不同尺寸的银-壳聚糖纳米粒子。纳米粒子的特征在于紫外可见吸收光谱（UV-Vis），扫描电子显微镜（SEM），差示扫描量热法（DSC），动态光散射（DLS）和激光多普勒电泳（LDE）。还通过琼脂扩散法评价纳米颗粒的抗菌性能。结果：银-壳聚糖纳米粒子的尺寸范围为21.9至175.3 nm，受壳聚糖分子量以及其他工艺条件的影响。尽管纳米颗粒在液体形式中不稳定，但是由于它们的低ζ电位而在固态下显示出良好的稳定性。 SEM图像表明纳米颗粒为球形。由于表面积的增加，纳米粒子对金黄色葡萄球菌的抗菌活性随粒径的减小而增加。通过在4°C下使用高壳聚糖MW和800 rpm的搅拌速度获得最小的粒径（21.9 nm）。结论：壳聚糖是制备纳米银的有效试剂。纳米粒子的大小可以通过改变壳聚糖分子量和工艺条件（例如温度和搅拌速度）来调节。

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