• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Comparative study of preparation, characterization and anticandidal activities of a chitosan silver nanocomposite (CAgNC) compared with low molecular weight chitosan (LMW-chitosan)
【24h】

Comparative study of preparation, characterization and anticandidal activities of a chitosan silver nanocomposite (CAgNC) compared with low molecular weight chitosan (LMW-chitosan)

机译：与低分子量壳聚糖（LMW-壳聚糖）相比，壳聚糖银纳米复合材料（CAGNC）的制备，表征和预油段活性的比较研究（LMW-壳聚糖）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A chitosan-silver nanocomposite (CAgNC) was synthesized in a green manner using low molecular weight chitosan (LMW-chitosan) and silver nitrate without applying external chemical reducing agents. The newly synthesized CAgNC was characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission electron microscopy (FE-SEM and FE-TEM), inductively coupled plasma-atomic emission spectroscopy (ICP-AES), particle size and zeta potential analysis. The average sizes of LMW-chitosan and CAgNC were 1776 +/- 23 nm and 240.1 +/- 23.6 nm, respectively. The zeta potential of CAgNC was observed as +41.1 mV. The AgNPs that are deposited on the chitosan matrix had average size ranges between 5 and 50 nm. The Ag content of the CAgNC was determined as 0.696 +/- 0.054% (w/w). The minimum inhibitory concentration (MIC) values of LMW-chitosan and CAgNC against Candida albicans were determined as 100 and 50 mu g mL(-1), whereas the minimum fungicidal concentration (MFC) values were recorded as 400 and 150 mu g mL(-1), respectively. Propidium iodide (PI) uptake results suggested that CAgNC affected the permeability of the cell membrane of C. albicans. Moreover, CAgNC induced the level of reactive oxygen species (ROS) at a higher level when compared to the LMW-chitosan, in a concentration-dependent manner. This report illustrates the eco-friendly approach for the reduction of silver ions using LMW-chitosan as a reducing agent to make a biologically active composite (CAgNC) and as a potential antifungal agent against C. albicans.
机译：使用低分子量壳聚糖（LMW-壳聚糖）和硝酸银，以绿色方式合成壳聚糖 - 银纳米复合材料（CAGNC），无需施加外部化学还原剂。新合成的CAGNC的特征在于UV可见光谱，傅里叶变换红外光谱（FT-IR），X射线衍射（XRD），场发射电子显微镜（Fe-SEM和FE-TEM），电感耦合等离子体原子发射光谱学（ICP-AES），粒度和Zeta电位分析。 LMW-Chitosan和CAGNC的平均尺寸分​​别为1776 +/- 23nm和240.1 +/- 23.6nm。 CAGNC的Zeta电位被观察为+ 41.1 mV。沉积在壳聚糖基质上的AgNP具有5至50nm之间的平均尺寸范围。 CAGNC的Ag含量确定为0.696 +/- 0.054％（w / w）。 LMW-壳聚糖和CAGNC对念珠菌醛糖醛的最小抑制浓度（MIC）值被确定为100和50μgmm（-1），而最小杀菌浓度（MFC）值被记录为400和150μgmm（ -1）分别。碘化丙啶（PI）摄取结果表明，CAGNC影响了C.古典人的细胞膜的渗透性。此外，在浓度依赖性的方式与LMW-壳聚糖相比，CAGNC在更高水平诱导反应性氧物种（ROS）的水平。本报告说明了使用LMW-壳聚糖作为还原剂将银离子还原的生态友好型方法，以制备生物活性复合物（CAGNC）和抵抗C. albicans的潜在抗真菌剂。

著录项

  • 来源
    《RSC Advances》 |2016年第40期|共7页
  • 作者

    Dananjaya S. H. S.; Kulatunga D. C. M.; Godahewa G. I.; Lee Jehee; De Zoysa Mahanama;

  • 作者单位

    Chungnam Natl Univ Coll Vet Med Daejeon 305764 South Korea;

    Chungnam Natl Univ Coll Vet Med Daejeon 305764 South Korea;

    Jeju Natl Univ Dept Marine Life Sci Jeju Si 690756 Jeju Self Gover South Korea;

    Jeju Natl Univ Dept Marine Life Sci Jeju Si 690756 Jeju Self Gover South Korea;

    Chungnam Natl Univ Coll Vet Med Daejeon 305764 South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号