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首页> 外文期刊>Turkish journal of chemistry >Synthesis, characterisation, and structural elucidation by spectral investigation (FT-IR, multinuclear NMR, mass spectrometry) of biologically active organotin(IV) compounds containing germanium
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Synthesis, characterisation, and structural elucidation by spectral investigation (FT-IR, multinuclear NMR, mass spectrometry) of biologically active organotin(IV) compounds containing germanium

机译：含锗的生物活性有机锡（IV）化合物的光谱研究（FT-IR，多核NMR，质谱），合成，表征和结构解析

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摘要

A new series of di and tri-organotin(IV) compoundscontaining germanium with the general formula R_{4-n}SnL_n wassynthesised by reaction of 3-triphenylgermanyl-3,3-dimethylpropionicacid with organotin(IV) oxides and organotin(IV) chloride in 2:1 and1:1 molar ratio, respectively, where R~=~CH_3, C_2H_5, n-C_4H_9,n-C_8H_{17}, and C_6H_5 n = 1 or 2 and L~=~triphenylgermanyl acidanion (GeC_{23} H_{23} O_2^-). These compounds were characterised byelemental analyses, FT-IR, multinuclear NMR (^1H, ^{13}C, ^{119}Sn),and mass spectrometry. The geometry around the tin atom wasdetermined and compared in both solution and solid states. Thespectroscopic results indicated that all the diorganotin(IV) compoundscontaining germanium possess trigonal-bipyramidal structures insolution and octahedral geometry in the solid state. A linearpolymeric trigonal-bipyramidal structure in the solid state and atetrahedral environment around the tin atom in non-coordinatingsolvents has been proposed for the triorganotin(IV) compounds. Allsynthesised compounds were tested in vitro against a number ofmicroorganisms to assess their biocidal properties and to correlatethem with the structures of the derivatives. These studies revealedthat such compounds show promising activity against different strainsof bacteria and fungi using the reference drugs imipenum andmiconazole.
机译：通过3-三苯基锗基-3,3-二甲基丙酸与有机锡（IV）氧化物和有机锡（IV）的反应合成了一系列新的含锗的通式R_ {4-n} SnL_n的二和三有机锡（IV）化合物摩尔比分别为2：1和1：1，其中R〜=〜CH_3，C_2H_5，n-C_4H_9，n-C_8H_ {17}和C_6H_5 n = 1或2和L〜=〜三苯基锗烷基酸阴离子（GeC_ {23 } H_ {23} O_2 ^-）。这些化合物的特征在于元素分析，FT-IR，多核NMR（^ 1H，^ {13} C，^ {119} Sn）和质谱。确定了锡原子周围的几何形状，并在溶液和固态下进行了比较。光谱结果表明，所有含锗的二有机锡（IV）化合物在固溶状态下均具有三角双锥体结构和八面体几何形状。对于三有机锡（IV）化合物，已经提出了在非配位溶剂中在锡原子周围的固态和四面体环境下的线性聚合的三角-双锥体结构。在体外对所有合成的化合物进行了抗多种微生物的测试，以评估其杀生物特性并将其与衍生物的结构相关联。这些研究表明，使用参考药物伊米木霉和咪康唑，这类化合物对细菌和真菌的不同菌株显示出有希望的活性。

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