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首页> 外文期刊>Turkish journal of chemistry >Synthesis, characterisation, and structural elucidation by spectral investigation (FT-IR, multinuclear NMR, mass spectrometry) of biologically active organotin(IV) compounds containing germanium
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Synthesis, characterisation, and structural elucidation by spectral investigation (FT-IR, multinuclear NMR, mass spectrometry) of biologically active organotin(IV) compounds containing germanium

机译：含锗的生物活性有机锡（IV）化合物的光谱研究（FT-IR，多核NMR，质谱），合成，表征和结构解析

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摘要

A new series of di and tri-organotin(IV) compounds containing germanium with the general formula R_(4-n)SnL_n was synthesised by reaction of 3-triphenylgermanyl-3,3-dimethylpropionic acid with organ-otin(IV) oxides and organotin(IV) chloride in 2:1 and 1:1 molar ratio, respectively, where R = CH3, C2H5, n-C4Hg, n-C8H_(17), and C6H5 n = 1 or 2 and L = triphenylgermanyl acid anion (GeC_(23) H_(23) O2~-). These compounds were characterised by elemental analyses, FT-IR, multinuclear NMR (~1H, ~(13)C, ~(119)Sn), and mass spectrometry. The geometry around the tin atom was determined and compared in both solution and solid states. The spectroscopic results indicated that all the diorganotin(IV) compounds containing germanium possess trigonal-bipyramidal structures in solution and octahedral geometry in the solid state. A linear polymeric trigonal-bipyramidal structure in the solid state and a tetrahedral environment around the tin atom in non-coordinating solvents has been proposed for the triorganotin(IV) compounds. All synthesised compounds were tested in vitro against a number of microorganisms to assess their biocidal properties and to correlate them with the structures of the derivatives. These studies revealed that such compounds show promising activity against different strains of bacteria and fungi using the reference drugs imipenum and miconazole.
机译：通过3-三苯基锗基-3,3-二甲基丙酸与有机锡氧化物的反应，合成了一系列新的含锗的通式R_（4-n）SnL_n的二和三有机锡（IV）化合物。分别以2：1和1：1的摩尔比氯化有机锡（IV），其中R = CH3，C2H5，n-C4Hg，n-C8H_（17）和C6H5 n = 1或2和L =三苯基锗烷基酸阴离子（ GeC_（23）H_（23）O2〜-）。这些化合物的特征在于元素分析，FT-IR，多核NMR（〜1H，〜（13）C，〜（119）Sn）和质谱。确定了锡原子周围的几何形状，并在溶液和固态下进行了比较。光谱结果表明，所有含锗的二有机锡（IV）化合物在溶液中均具有三角双锥体结构，并且在固态下具有八面体几何形状。对于三有机锡（IV）化合物，已经提出了在非配位溶剂中处于固态的线性聚合物三角双锥体结构和围绕锡原子的四面体环境。所有合成的化合物都针对多种微生物进行了体外测试，以评估其杀生物特性并将其与衍生物的结构相关联。这些研究表明，使用参考药物伊米木霉和咪康唑时，此类化合物对细菌和真菌的不同菌株显示出有希望的活性。

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