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首页> 外文期刊>World Journal of AIDS >Prevalence of Asymptomatic Bacteriuria in HIV Infected Patients in a Tertiary Hospital in Lagos, Nigeria
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Prevalence of Asymptomatic Bacteriuria in HIV Infected Patients in a Tertiary Hospital in Lagos, Nigeria

机译：尼日利亚拉各斯一家三级医院的HIV感染患者无症状细菌尿的患病率

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Background: People living with Human Immunodeficiency Virus (HIV) are more predisposed to urinary tract infections due to suppression of their immunity by the virus. Asymptomatic bacteriuria is associated with an increased risk of symptomatic urinary tract infection and the latter being an important contributor to development of chronic renal failure, hypertension and toxaemia of pregnancy. The aim of this study was to determine the prevalence of asymptomatic bacteriuria in HIV-infected patients and proffer a recommendation on the need or otherwise to screen. Methods: This was a cross sectional study of treatment-naive HIV-infected patients attending the HIV clinics of Lagos State University Teaching Hospital (LASUTH), Ikeja. A single voided aseptically collected mid-stream urine (MSU) was obtained from each patient and all samples processed immediately, were sent for urinalysis and culture. Isolates were considered significant if there were ≥105 colony forming unit/mL (CFU/mL) with 2 or less isolates, doubtful significance if 5 CFU/mL. Significant isolates were selected for identification. Data were analyzed using SPSS version 16.0 (Statistical Package for Social Sciences, Inc., Chicago, Ill). Results: A total of 156 consenting participants were recruited into the study. The mean age was 36.45 ± 8.65 years. There were 60 of 156 (38.4%) males and 96 of 156 (61.56%) females. Only 33 of 156 (21.2%) had significant bacteriuria, out of the 33 participants, 19 (57.8%) were asymptomatic, while 14 of 33 (42.4%) had significant growth but were symptomatic or on antibiotics. E. coli was isolated in 9 of 19 (47.3%), followed by Staph aureus 4 of 19 (21.05%). Conclusion: More than half of participants who had significant growth had asymptomatic bacteriuria, while one-fifth of all patients had significant growth. Considering this statistics, screening for or treatment of asymptomatic bacteriuria may be recommended in all HIV-infected patients.
机译：背景：感染人类免疫缺陷病毒（HIV）的人由于感染病毒而抑制了免疫力，因此更容易发生尿路感染。无症状菌尿与症状性尿路感染的风险增加有关，后者是慢性肾功能衰竭，高血压和妊娠毒血症发展的重要因素。这项研究的目的是确定感染HIV的患者中无症状菌尿的患病率，并就是否需要筛查提出建议。方法：这是一项横断面研究，涉及未经治疗的，感染过Ikeja州拉各斯州立大学教学医院（LASUTH）HIV诊所的艾滋病毒感染患者。从每位患者中获取一个单一的，无菌收集的中游尿液（MSU），并立即处理所有样品，然后送去进行尿液分析和培养。如果菌落形成单位/ mL（CFU / mL）≥105，且分离株少于或等于2，则认为分离株具有重要意义;如果5 CFU / mL，则分离株的意义令人怀疑。选择重要的分离物进行鉴定。使用SPSS 16.0版（社会科学统计软件包，伊利诺伊州芝加哥）分析数据。结果：总共156名同意参加的受试者被纳入研究。平均年龄为36.45±8.65岁。 156名男性中有60名（38.4％），而156名女性中有96名（61.56％）。 156名患者中只有33名（21.2％）有显着的细菌尿，在33名参与者中，有19名患者（57.8％）无症状，而33名参与者中的14名（42.4％）有明显的增长，但有症状或使用了抗生素。分离出的大肠杆菌中有19的9（47.3％），接着是金黄色葡萄球菌的19占4（21.05％）。结论：显着增长的参与者中有一半以上患有无症状菌尿，而所有患者中有五分之一具有显着增长。考虑到这一统计数据，可能建议对所有感染HIV的患者进行无症状菌尿的筛查或治疗。

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