TNBC vs. Non-TNBC: A Five-Year Retrospective Review of Differences in Mean Age, Family History, Smoking History and Stage at Diagnosis at an Inner City University Program

Khurram Tariq; Fauzia Rana

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TNBC vs. Non-TNBC: A Five-Year Retrospective Review of Differences in Mean Age, Family History, Smoking History and Stage at Diagnosis at an Inner City University Program

机译：TNBC与非TNBC：对内城大学项目诊断时平均年龄，家族史，吸烟史和诊断阶段差异的五年回顾性回顾

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Background: In recent years, breast cancer has been classified on the basis of estrogen or progesterone receptor (ER/PR) status and whether the human epidermal growth factor 2 receptor (HER2eu) protein is overexpressed. Based on this system, breast cancer is broadly divided into the triple negative breast cancer (TNBC) and the non-TNBC subtypes. TNBC is a subtype of breast cancer, notable for its propensity to metastasize early and display a comparatively more aggressive course than its non-TNBC counterpart. Certain clinico-pathologic and demographic risk factors have been associated with breast cancer. In this study, we aim to compare mean age, ethnicity, family history, tobacco use and stage at presentation between TNBC and non-TNBC subtypes at our inner city university program. Methods: We reviewed data in our tumor registry between January 2000 and December 2005 with particular attention to mean age, race, family history, tobacco use and stage at presentation. We found a total of 445 patients with various subtypes of breast cancers. We included only those patients in whom the status of both ER/PR and the status of Her2eu protein overexpression were recorded. Our strict selection criteria lead to an exclusion of about 103 patients. Out of the remaining 342 patients, 39 were TNBC and 303 were non-TNBC. Results: Mean age of onset for TNBC vs. non-TNBC patients was 59.87 ± 15.67 years vs. 60.09 ± 13.98 years respectively (P = 0.9272). In terms of ethnicity, TNBC vs. non-TNBC patients had the following racial backgrounds: black, 58.97% vs. 39.27%; white, 35.90% vs. 57.76%; Chinese, 2.56% vs. 0.99%; others, 2.57% vs. 1.98% respectively (P = 0.004, OR = 2.755). Comparisons with respect to a history of tobacco abuse for TNBC vs. non-TNBC patients revealed a positive smoking history in 20.51% vs. 27.72% whereas there was no former or current smoking history in 71.79% vs. 61.72% respectively (P = 0.4385). Comparison of family history of a breast cancer in TNBC vs. non-TNBC patients showed that positive family history of breast cancer was seen in 30.77% vs. 33.33%, no family history of cancer was seen in 51.28% vs. 51.82% and unknown 17.95% vs. 14.85% (P = 0.8384). Pathologic stage at the time of diagnosis for TNBC vs. non-TNBC patients was as follows: stage 0, 15.79% vs. 11.37% (P = 0.4332); stage 1, 34.21% vs. 30.98% (P = 0.6890); stage 2, 28.98% vs. 37.25% (P = 0.3205); stage 3, 18.42% vs. 17.25% (P = 0.0.8591); and stage 4, 3.63% vs. 3.14% (P = 0.8651). Analysis using Chi-square test revealed χ2 value of 0.855. Conclusion: Our results add to the growing body of evidence pertaining to the association of certain demographic and clinico-pathologic characteristics in women with breast cancer. We found that in our patient population, there is a significant ethnic predisposition for the two types of breast cancers that we studied. African Americans were more likely to have TNBC compared to the higher frequency of non-TNBC in white females. We did not find a significant difference in mean age, cigarette smoking, family history and stage at diagnosis between the TNBC and non-TNBC breast cancer patients. These findings are all consistent with the previously published research studies.World J Oncol. 2013;4(6):241-247doi: http://dx.doi.org/10.4021/wjon738w

机译：背景：近年来，已根据雌激素或孕激素受体（ER / PR）的状态以及人类表皮生长因子2受体（HER2 / neu）蛋白是否过表达对乳腺癌进行了分类。基于此系统，乳腺癌大致分为三阴性乳腺癌（TNBC）和非TNBC亚型。 TNBC是乳腺癌的一种亚型，以其早期转移倾向和相对于非TNBC而言更具侵略性。某些临床病理和人口统计学危险因素与乳腺癌有关。在这项研究中，我们旨在比较我们内城大学计划中TNBC和非TNBC亚型的平均年龄，种族，家族史，烟草使用和分期。方法：我们回顾了2000年1月至2005年12月间肿瘤登记中的数据，特别注意平均年龄，种族，家族病史，吸烟情况和呈报阶段。我们发现总共445名患有各种乳腺癌亚型的患者。我们仅包括记录了ER / PR和Her2 / neu蛋白过表达状态的患者。我们严格的选择标准导致大约103名患者被排除在外。在其余的342例患者中，有39例为TNBC，有303例为非TNBC。结果：TNBC与非TNBC患者的平均发病年龄分别为59.87±15.67岁和60.09±13.98岁（P = 0.9272）。就种族而言，TNBC与非TNBC患者具有以下种族背景：黑人，58.97％对39.27％;白色，分别为35.90％和57.76％;中文（2.56％vs. 0.99％）;其他分别为2.57％和1.98％（P = 0.004，OR = 2.755）。比较TNBC与非TNBC患者的吸烟史，发现吸烟史为阳性的比例分别为20.51％和27.72％，而既往没有吸烟史或现在的吸烟史分别为71.79％和61.72％（P = 0.4385））。比较TNBC和非TNBC患者的乳腺癌家族史，发现阳性乳腺癌家族史的发生率分别为30.77％和33.33％，未发现乳腺癌家族史的发生率分别为51.28％和51.82％，并且未知17.95％和14.85％（P = 0.8384）。 TNBC与非TNBC患者在诊断时的病理分期如下：0分期，15.79％vs. 11.37％（P = 0.4332）;第一阶段，分别为34.21％和30.98％（P = 0.6890）;第二阶段，28.98％对37.25％（P = 0.3205）;第三阶段，分别为18.42％和17.25％（P = 0.0.8591）;第四阶段，分别为3.63％和3.14％（P = 0.8651）。使用卡方检验的分析表明χ2值为0.855。结论：我们的结果增加了与乳腺癌女性中某些人口统计学和临床病理特征相关的证据。我们发现在我们的患者人群中，我们研究的两种类型的乳腺癌存在明显的种族倾向。与白人女性中非TNBC的发生频率相比，非裔美国人更容易患有TNBC。在TNBC和非TNBC乳腺癌患者之间，我们在平均年龄，吸烟，家族史和诊断阶段方面没有发现显着差异。这些发现均与先前发表的研究一致。 2013; 4（6）：241-247doi：http：//dx.doi.org/10.4021/wjon738w

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《World Journal of Oncology》 |2013年第6期|共7页
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Khurram Tariq; Fauzia Rana;
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TNBC vs. Non-TNBC: A Five-Year Retrospective Review of Differences in Mean Age, Family History, Smoking History and Stage at Diagnosis at an Inner City University Program

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