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首页> 外文期刊>World Journal of Oncology >Expression of HLA-I, CD8, and CD4 and Their Clinical Significance in Cervical Cancer
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Expression of HLA-I, CD8, and CD4 and Their Clinical Significance in Cervical Cancer

机译：HLA-1，CD8和CD4在宫颈癌中的表达及其临床意义

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Background: The local tissue immune status may play a role in the progression of cervical cancer. The aim of our study is to examine the expression of HLA-I, CD8 and CD4 in various cervical diseases and investigate their association with cervical cancer.Methods: We chose the tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and peri-cancer tissues, and then detected the expression of HLA-I, CD8 and CD4 using SP immunohistochemistry. The associations of the expression of HLA-I, CD8 and CD4 with the clinicopathologic profiles of the patients were analyzed.Results: The percentage of positive tissue staining of HLA class I antigen in cervical cancer, CIN, chronic cervicitis and peri-cancer tissues were 40%, 95%, 100.0% and 100.0%, respectively. And the percentage of CD8 in various tissues was 35%, 95%, 100% and 100.0%, respectively. The positive tissue staining percentage of CD4 in the tissues above was 45%, 80%, 100% and 100%, respectively. The percentage of positive tissue staining of HLA-I, CD8 and CD4 were significantly lower in tissues of cervical cancer when compared with other tissues (P 0.05). A positive correlation was found between HLA-I and CD8 expression (Spearman's correlation rs = 0.913, P < 0.001).Conclusions: The expression of HLA-I, CD8 and CD4 are down-regulated or deleted in CIN and cervical cancer, and they may play important roles in the development and progression of CIN and cervical cancer.doi:10.4021/wjon286w
机译：背景：局部组织的免疫状态可能在宫颈癌的进展中起作用。本研究的目的是检查HLA-I，CD8和CD4在各种宫颈疾病中的表达，并探讨它们与宫颈癌的关系。方法：我们选择了宫颈癌，宫颈上皮内瘤变（CIN），慢性宫颈炎和然后用SP免疫组织化学检测HLA-1，CD8和CD4的表达。结果：分析宫颈癌，CIN，慢性宫颈炎和癌旁组织中HLA I类抗原阳性组织染色的百分比，并分析HLA-1，CD8和CD4的表达与患者临床病理特征的关系。分别为40％，95％，100.0％和100.0％。 CD8在各种组织中的百分比分别为35％，95％，100％和100.0％。上方组织中CD4的阳性组织染色百分比分别为45％，80％，100％和100％。与其他组织相比，宫颈癌组织中HLA-1，CD8和CD4阳性组织染色的百分比显着降低（P 0.05）。 HLA-1与CD8的表达呈正相关（Spearman相关系数rs = 0.913，P <0.001）。结论：CIN和宫颈癌中HLA-1，CD8和CD4的表达下调或缺失可能在CIN和宫颈癌的发生和发展中起重要作用。doi：10.4021 / wjon286w

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