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首页> 外文期刊>World Journal of Oncology >Hyaluronan (HA) and H11 Antigen (HABP) Expression in Cervical Cancer Sections and Their Significances as Prominent Markers
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Hyaluronan (HA) and H11 Antigen (HABP) Expression in Cervical Cancer Sections and Their Significances as Prominent Markers

机译：透明质酸（HA）和H11抗原（HABP）在宫颈癌切片中的表达及其作为重要标志物的意义

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Background: Cancer is a disease characterized by a population of cells that grow and divide without respect to normal limits, invade and destroy adjacent tissues, and may spread to distant anatomic sites through a process called metastasis. These malignant properties of cancers differentiate them from benign tumors, which are self-limited in their growth and do not invade or metastasize for the development and progression of tumor cells. Cancer is a result of multistep process involving accumulation of genetic alternation, which results in loss of cell-cell interaction, increasing invasive migration, loss of control in cell division and abnormal matrix assembly. Carcinoma of the cervix is one of the most common malignancies. Cervical differentiation requires changes in the composition and structure of extracellular matrix. However, the biological roles of Hyaluronan (HA) in cervical remodeling are still under investigation and HA-receptors are not studied during cervical pathological remodeling. Hence, in the current study we investigated the expression and association of extracellular matrix components namely hyaluronan-hyaluronic acid binding protein (H11 antigen) (HA-HABP) in normal and invasive lesion in cervical tissue section slides. Methods and Results: Cervical tissues from normal and suspected cancer patients from hospitals were examined. Immunohistochemistry was performed with specific HA probe, b. PG (biotinylated proteoglycan) and anti-HABP antibody H11B2C2 for H11 antigen. HA and H11 antigen are overexpressed in well-differentiated tumors during progression.Conclusions: We conclude that the expression of HA and H11 antigen and their interaction are very important in identifying cervical cancers and probably H11 antigen can be used as a biomarker in identifying the tumor cells in cervical lesions.doi:10.4021/wjon287e
机译：背景：癌症是一种以细胞群为特征的疾病，该细胞群在不受正常限制的情况下生长和分裂，侵袭和破坏邻近组织，并可能通过称为转移的过程扩散到遥远的解剖部位。癌症的这些恶性特性使它们与良性肿瘤区分开来，良性肿瘤的生长受到自身限制，并且不会侵袭或转移肿瘤细胞的发展和进程。癌症是涉及遗传交替积累的多步骤过程的结果，该过程导致细胞间相互作用的丧失，侵袭性迁移的增加，细胞分裂控制的丧失和基质组装异常。子宫颈癌是最常见的恶性肿瘤之一。宫颈分化需要改变细胞外基质的组成和结构。但是，乙酰透明质酸（HA）在宫颈重塑中的生物学作用仍在研究中，在宫颈病理重塑中尚未研究HA受体。因此，在当前的研究中，我们调查了宫颈组织切片中正常和浸润性病变中细胞外基质成分（透明质酸-透明质酸结合蛋白（H11抗原）（HA-HABP））的表达和关联。方法和结果：检查了来自医院的正常和疑似癌症患者的宫颈组织。用特异性HA探针进行免疫组织化学，b。 PG（生物素化蛋白聚糖）和H11抗原的抗HABP抗体H11B2C2。结论：我们得出结论，HA和H11抗原的表达及其相互作用对鉴定宫颈癌非常重要，并且H11抗原可能可以用作鉴定肿瘤的生物标志物。宫颈病变细胞.doi：10.4021 / wjon287e

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