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首页> 外文期刊>Hepatitis Research and Treatment >Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia
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Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia

机译：哥伦比亚肝病科收治的终末期肝病患者的病因学和病毒基因型

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摘要

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption.
机译：乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染是与世界末期肝病相关的主要危险因素。在哥伦比亚第二大城市麦德林，对进入重要肝病科的末期肝病病例进行了研究。在这项前瞻性研究中招募的131名患者中，有71％被诊断为肝硬化，12.2％为HCC和16.8％为肝硬化和HCC。关于这些患者的危险因素，饮酒是最常见的（37.4％），其次是病毒病因学（17.6％）。对来自具有HCV或HBV感染血清学标志物的患者的血液和/或肝组织样本进行了表征;根据HCV 5'UTR和HBV S基因的系统发育分析，分离株分别属于HCV / 1和HBV / F3。这些结果证实了在哥伦比亚患有肝病的患者中存在与不良临床结果相关的菌株。另外，在HCC病例中鉴定出HBV基础核心启动子双重突变体。在这里，我们显示了对哥伦比亚人肝硬化和/或HCC的首次研究，这些患者的HBV和HCV分子特征。病毒病因不是该队列的主要危险因素，而是饮酒。

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