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首页> 外文期刊>Hong Kong Journal of Paediatrics >Cytokine Response Differences in Enterovirus 71 and Other Enterovirus-caused Hand Foot and Mouth Disease Complicated with Aseptic Meningitis
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Cytokine Response Differences in Enterovirus 71 and Other Enterovirus-caused Hand Foot and Mouth Disease Complicated with Aseptic Meningitis

机译：肠道病毒71和其他由肠道病毒引起的手足口病并发无菌性脑膜炎的细胞因子反应差异

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Objectives: In order to identify EV71 meningitis-specific cytokine alteration in plasma and cerebrospinalfluid (CSF) that differs from other enterovirus (OEV)-infected ones, we compared data obtained fromHFMD patients with EV71 meningitis or OEV meningitis. Methods: We elucidated the cytokine networkbased on the cytokine (IL-4, IFN-γ, IL-17A, TGF-β1) profiles both in plasma and CSF from hand foot andmouth disease (HFMD), cases with aseptic meningitis (AM) due to EV71 (n=37) or OEV (n=26) infectionusing enzyme-linked immunosorbent assay. Plasma from healthy control (n=20) or CSF from febrileconvulsion subjects (n=20) was run as control. Aetiological diagnosis was based on the detection ofenteroviral RNA in the throat swab by real-time PCR. Results: Plasma IFN-γ levels were much higher inHFMD patients than controls, but no difference was shown between EV71 and OEV-infected ones.Meanwhile, plasma IL-17A levels in OEV-infected cases were significantly lower than EV71-infectedsubjects without differing from healthy controls. Furthermore, CSF IL-17A levels were much higher inEV71-infected groups than OEV-infected ones or subjects with febrile convulsion. In addition, no significantcorrelation was found between plasma cytokine levels and CSF corresponding cytokine levels. Similarly,there was no remarkable relationship between CSF cytokine levels and CSF leukocytes counts. Conclusion:EV71 cause different immune responses from OEV. IL-17A in the central nervous system, as well as inblood, appeared to be involved in the pathogenesis of EV71 AM.
机译：目的：为了鉴定血浆和脑脊髓液（CSF）中的EV71脑膜炎特异性细胞因子改变与其他肠病毒（OEV）感染的不同，我们比较了从HFMD EV71脑膜炎或OEV脑膜炎患者获得的数据。方法：我们根据手足口病（HFMD），无菌性脑膜炎（AM）病例的血浆和脑脊液中的细胞因子（IL-4，IFN-γ，IL-17A，TGF-β1）特征阐明了细胞因子网络使用酶联免疫吸附法检测EV71（n = 37）或OEV（n = 26）感染。将健康对照组的血浆（n = 20）或高热惊厥受试者的CSF（n = 20）作为对照。病原学诊断基于实时PCR检测喉拭子中的肠病毒RNA。结果：HFMD患者血浆IFN-γ水平明显高于对照组，但EV71和OEV感染者之间无差异;同时，OEV感染者血浆IL-17A水平显着低于EV71感染者，与对照组无差异健康对照。此外，EV71感染组的脑脊液IL-17A水平远高于OEV感染组或高热惊厥患者。另外，在血浆细胞因子水平和CSF相应的细胞因子水平之间没有发现显着的相关性。同样，脑脊液细胞因子水平与脑脊液白细胞计数之间也没有显着关系。结论：EV71可引起与OEV不同的免疫反应。中枢神经系统和血液中的IL-17A似乎与EV71 AM的发病机理有关。

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