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microPIR2: a comprehensive database for human–mouse comparative study of microRNA–promoter interactions

机译:microPIR2:用于人与小鼠的microRNA-启动子相互作用比较研究的综合数据库

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microRNA (miRNA)–promoter interaction resource (microPIR) is a public database containing over 15 million predicted miRNA target sites located within human promoter sequences. These predicted targets are presented along with their related genomic and experimental data, making the microPIR database the most comprehensive repository of miRNA promoter target sites. Here, we describe major updates of the microPIR database including new target predictions in the mouse genome and revised human target predictions. The updated database (microPIR2) now provides ~80 million human and 40 million mouse predicted target sites. In addition to being a reference database, microPIR2 is a tool for comparative analysis of target sites on the promoters of human–mouse orthologous genes. In particular, this new feature was designed to identify potential miRNA–promoter interactions conserved between species that could be stronger candidates for further experimental validation. We also incorporated additional supporting information to microPIR2 such as nuclear and cytoplasmic localization of miRNAs and miRNA–disease association. Extra search features were also implemented to enable various investigations of targets of interest. Database URL: http://www4a.biotec.or.th/micropir2
机译:microRNA(miRNA)-启动子相互作用资源(microPIR)是一个公共数据库,其中包含位于人类启动子序列内的超过1500万个预测的miRNA目标位点。这些预测的靶标及其相关的基因组和实验数据都可以得到展示,从而使microPIR数据库成为miRNA启动子靶标位点最全面的数据库。在这里,我们描述了microPIR数据库的主要更新,包括小鼠基因组中的新目标预测和修订后的人类目标预测。现在更新的数据库(microPIR2)提供了约8000万人类和4000万小鼠预测的目标位点。除了作为参考数据库外,microPIR2还是用于比较分析人鼠直系同源基因启动子上靶位点的工具。尤其是,此新功能旨在识别物种之间保守的潜在miRNA启动子相互作用,这些相互作用可能是进行进一步实验验证的更强候选者。我们还将其他支持信息纳入了microPIR2中,例如miRNA的核和细胞质定位以及miRNA与疾病的关联。此外,还实现了额外的搜索功能,可以对感兴趣的目标进行各种调查。数据库URL:http://www4a.biotec.or.th/micropir2

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