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首页> 外文期刊>Dataset Papers in Science >Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin
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Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin

机译：长期链脲佐菌素糖尿病大鼠组织中激素敏感性腺苷酸环化酶系统的变化及鼻内胰岛素的影响

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One of the causes of complications in type 1 diabetes mellitus (T1DM) is the changes in adenylyl cyclase (AC) signaling system, identified on the early stages of the disease. However, the most significant disturbances in this system occur on the later stages of T1DM, which ultimately leads to severe complications, but functional state of the AC system in late T1DM is poorly understood. The aim of this work was to study alterations in AC system sensitive to biogenic amines and polypeptide hormones in the heart, brain, and testes of male rats with long-term, 7-month, streptozotocin T1DM and to assess the influence on them of 135-day therapy with intranasal insulin. It was shown that AC effects ofβ-adrenergic agonists in the heart, serotonin receptor agonists and PACAP-38 in the brain, chorionic gonadotropin and PACAP-38 in the testes, and somatostatin in all investigated tissues in long-term T1DM were drastically decreased. The treatment with intranasal insulin (0.48 IU/day) significantly restored these effects. The results were obtained suggesting that long-term T1DM induces significant alterations in hormone-sensitive AC system in the heart, brain, and testes that are much more pronounced, compared with short-term T1DM, and include a large number of hormonal regulations.
机译：1型糖尿病（T1DM）并发症的原因之一是在疾病的早期发现的腺苷酸环化酶（AC）信号系统的变化。但是，该系统中最严重的故障发生在T1DM的后期，最终导致严重的并发症，但是人们对T1DM晚期的AC系统的功能状态了解甚少。这项工作的目的是研究对长期，为期7个月的链脲佐菌素T1DM的雄性大鼠的心脏，大脑和睾丸中的生物胺和多肽激素敏感的交流系统的变化，并评估对它们的影响135鼻内胰岛素治疗。结果表明，长期T1DM患者心脏中β-肾上腺素能激动剂，大脑中5-羟色胺受体激动剂和PACAP-38，睾丸绒毛膜促性腺激素和PACAP-38的AC作用以及生长抑素均显着降低。鼻内胰岛素治疗（0.48 IU /天）可显着恢复这些作用。获得的结果表明，与短期T1DM相比，长期T1DM会引起心脏，大脑和睾丸激素敏感性AC系统的显着变化，这种变化与短期T1DM相比更为明显，并且包括大量的激素调节。

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