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In VivoAntioxidant Activity of Topical Cream ofCassia toraL. Leaves Extract

机译：决明子外用霜的体内抗氧化活性。叶提取物

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Objective. The aim of study was to determine thein vivoantioxidant activity of newly formulated O/W cream of methanolic extract ofCassia toraL. leaves.Methods. Oil in water (O/W) creams (0.05%, 0.1%, and 0.2%), cream base, methanolic extract ofC. toraL. leaves (CTM), and standard (0.05% tretinoin cream) were screened forin vivoantioxidant activity. The ultraviolet- (UV-) B-induced rats were treated with different standard, O/W creams, cream base, and methanolic extract ofCassia toraL. leaves (CTM). The parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels were assessed.Results. The result of acute dermal toxicity shows that the creams were safe up to 2000 mg/kg (topically). Exposure of ultraviolet light of medium wave (UV-B light) decreased the level of GSH, CAT, and SOD and increased the LPO level.Concluding Remarks. We conclude that topical O/W creams ofC. toraL. prevent the oxidative stress induced in rats by exposure to UV-B light by virtue of itsin vivoantioxidant property, and these findings help to understand the mechanism of the antipsoriatic activity of O/W creams ofC. toraL. in UV-B-induced psoriasis in the rat.
机译：目的。研究目的是确定新配制的决明子甲醇提取物的O / W霜的体内抗氧化活性。叶子。方法。水包油型（O / W）乳膏（0.05％，0.1％和0.2％），乳膏基质，C的甲醇提取物。 toraL。筛选叶子（CTM）和标准品（0.05％维甲酸霜）的体内抗氧化活性。紫外线（UV-）B诱导的大鼠分别用不同标准的O / W乳膏，乳膏基质和决明子的甲醇提取物处理。离开（CTM）。评估了脂质过氧化（LPO），还原型谷胱甘肽（GSH），超氧化物歧化酶（SOD）和过氧化氢酶（CAT）等参数。急性皮肤毒性反应的结果表明，该乳霜在2000μmg/ kg（局部）以下安全。中波紫外线（UV-B光）的照射降低了GSH，CAT和SOD的水平，并增加了LPO的水平。我们得出结论，C的局部O / W面霜。 toraL。由于其体内抗氧化特性，可以防止因暴露于UV-B光线而引起的大鼠氧化应激反应，这些发现有助于了解C的O / W面霜的抗银屑病活性机制。 toraL。 UV-B诱导的牛皮癣在大鼠中的作用。

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