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首页> 外文期刊>Dental Journal: Majalah Kedokteran Gigi >Proliferation of odontoblast-like cells following application of a combination of calcium hydroxide and propolis
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Proliferation of odontoblast-like cells following application of a combination of calcium hydroxide and propolis

机译：应用氢氧化钙和蜂胶组合后成牙本质细胞样细胞的增殖

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Background: One purpose of operative dentistry is the maintenance of healthy pulp by reducing the need for root canal treatment and the possibility of undesirable scenarios such as tooth loss. Propolis is a plant-derived substance that contains a resin produced by honeybees belonging to the Apis mellifera species. Purpose: This study aimed to investigate the effect of a combination of calcium hydroxide (Ca(OH) 2 ) and propolis extract on odontoblast-like cell proliferation in Wistar rats (Rattus norvegicus). Methods: This research constituted a true experimental laboratory-based investigation with post-test control group design. Thirty Wistar rats were randomly divided into six groups. The first molar pulp of each sample was perforated on occlusal surfaces using a low speed round bur. On day 3, the samples were divided into six groups (n=10): Group I: control; Group II: Ca(OH )2 + 11% ; propolis extract; Group III: Ca(OH) 2 + aquadest, and on day 7: Group IV: control; Group V: Ca(OH )2 + 11% propolis extract; Group VI: Ca(OH) 2 + aquadest. All samples were filled with restorative material. They were subsequently sacrificed after 3 and 7 days post-pulp capping administration and the afflicted tooth extracted for hematoxylin and eosin (H&E) staining. The resulting data was subjected to statistical analysis to ascertain the proliferation of odontoblast-like cells. The significance of differences between the groups was determined by a one-way ANOVA test followed by a post hoc Tuckey HSD. A p-value 0.05 was considered to be significant. Results: On day 3, a significant difference existed between group II (Ca(OH) 2 –propolis) and group I (control group) and group III (Ca(OH) 2 –aquades), whereas Ca(OH) 2 –propolis revealed that the proliferation of odontoblast-like cells was higher. Meanwhile, on day 7, there was a significant difference between all groups whereas, with regard to Ca(OH)2–propolis, the proliferation of odontoblast-like cells in group V was higher. Conclusion: Application of combination of Ca(OH) 2 -propolis extract can increase the proliferation of odontoblast-like cells in pulp tissue on days 3 and 7.
机译：背景：牙科手术的目的之一是通过减少对根管治疗的需要以及减少诸如牙齿脱落等不良情况的可能性来维持牙髓健康。蜂胶是一种植物来源的物质，其中含有一种由蜜蜂属的蜜蜂产生的树脂。目的：本研究旨在研究氢氧化钙（Ca（OH）2）和蜂胶提取物的组合对Wistar大鼠（Rattus norvegicus）成牙本质细胞样细胞增殖的影响。方法：本研究构成了一个真正的基于实验实验室的调查，并具有测试后对照组的设计。将三十只Wistar大鼠随机分为六组。使用低速圆形钻针在每个咬合面打磨每个样品的第一磨牙牙髓。在第3天，将样品分成六组（n ＝ 10）。第二组：Ca（OH）2 + 11％;蜂胶提取物第III组：Ca（OH）2 +亲水，第7天：第IV组：对照组;第V组：Ca（OH）2 + 11％蜂胶提取物;第六组：Ca（OH）2 +浅绿色。所有样品都充满了修复材料。在给纸浆加盖后3天和7天后，将它们随后处死，并取出患病的牙齿进行苏木精和曙红（H＆E）染色。对所得数据进行统计分析，以确定成牙本质细胞样细胞的增殖。两组之间差异的显着性由单向ANOVA检验和事后塔基HSD确定。 p值<0.05被认为是显着的。结果：在第3天，第II组（Ca（OH）2-蜂胶）与第I组（对照组）和第III组（Ca（OH）2-aquades）之间存在显着差异，而Ca（OH）2-蜂胶揭示成牙本质细胞样细胞的增殖更高。同时，在第7天，所有组之间都有显着差异，而就Ca（OH）2-蜂胶而言，V组中成牙本质细胞样细胞的增殖更高。结论：联合应用Ca（OH）2-蜂胶提取物可以增加牙髓组织中成牙本质细胞样细胞在第3天和第7天的增殖。

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